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Genomic evolution and chemoresistance in germ-cell tumours

Author

Listed:
  • Amaro Taylor-Weiner

    (Harvard University
    Cancer Program, Broad Institute of MIT and Harvard)

  • Travis Zack

    (Harvard University
    Health Sciences and Technology, Harvard Medical School)

  • Elizabeth O’Donnell

    (Dana-Farber Cancer Institute
    Massachusetts General Hospital)

  • Jennifer L. Guerriero

    (Dana-Farber Cancer Institute)

  • Brandon Bernard

    (Dana-Farber Cancer Institute)

  • Anita Reddy

    (Harvard Medical School)

  • G. Celine Han

    (Cancer Program, Broad Institute of MIT and Harvard
    Dana-Farber Cancer Institute)

  • Saud AlDubayan

    (Boston Children’s Hospital
    King Saud bin Abdulaziz University for Health Sciences)

  • Ali Amin-Mansour

    (Cancer Program, Broad Institute of MIT and Harvard)

  • Steven E. Schumacher

    (Cancer Program, Broad Institute of MIT and Harvard)

  • Kevin Litchfield

    (The Institute of Cancer Research
    William Harvey Research Institute, Queen Mary University London)

  • Clare Turnbull

    (The Institute of Cancer Research
    William Harvey Research Institute, Queen Mary University London)

  • Stacey Gabriel

    (Cancer Program, Broad Institute of MIT and Harvard)

  • Rameen Beroukhim

    (Cancer Program, Broad Institute of MIT and Harvard
    Dana-Farber Cancer Institute)

  • Gad Getz

    (Cancer Program, Broad Institute of MIT and Harvard
    Massachusetts General Hospital)

  • Scott L. Carter

    (Cancer Program, Broad Institute of MIT and Harvard
    Center for Cancer Precision Medicine, Dana-Farber Cancer Institute
    Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA
    Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA)

  • Michelle S. Hirsch

    (Brigham and Women’s Hospital)

  • Anthony Letai

    (Dana-Farber Cancer Institute)

  • Christopher Sweeney

    (Dana-Farber Cancer Institute)

  • Eliezer M Van Allen

    (Cancer Program, Broad Institute of MIT and Harvard
    Dana-Farber Cancer Institute
    Center for Cancer Precision Medicine, Dana-Farber Cancer Institute)

Abstract

Genomic analyses show that primary germ-cell tumours are highly enriched for chromosomal reciprocal loss of heterozygosity, mutations in KRAS and have high mitochondrial priming, providing insight into chemosensitivity and the evolution of chemoresistance in this disease.

Suggested Citation

  • Amaro Taylor-Weiner & Travis Zack & Elizabeth O’Donnell & Jennifer L. Guerriero & Brandon Bernard & Anita Reddy & G. Celine Han & Saud AlDubayan & Ali Amin-Mansour & Steven E. Schumacher & Kevin Litch, 2016. "Genomic evolution and chemoresistance in germ-cell tumours," Nature, Nature, vol. 540(7631), pages 114-118, December.
    • Handle: RePEc:nat:nature:v:540:y:2016:i:7631:d:10.1038_nature20596
    DOI: 10.1038/nature20596
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    Cited by:

    1. Wilfried Engl & Aliz Kunstar-Thomas & Siyi Chen & Woei Shyuan Ng & Hendrik Sielaff & Ziqing Winston Zhao, 2024. "Single-molecule imaging of SWI/SNF chromatin remodelers reveals bromodomain-mediated and cancer-mutants-specific landscape of multi-modal DNA-binding dynamics," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Thomas R. W. Oliver & Lia Chappell & Rashesh Sanghvi & Lauren Deighton & Naser Ansari-Pour & Stefan C. Dentro & Matthew D. Young & Tim H. H. Coorens & Hyunchul Jung & Tim Butler & Matthew D. C. Nevill, 2022. "Clonal diversification and histogenesis of malignant germ cell tumours," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    3. Lin Xu & Joshua L. Pierce & Angelica Sanchez & Kenneth S. Chen & Abhay A. Shukla & Nicholas J. Fustino & Sarai H. Stuart & Aditya Bagrodia & Xue Xiao & Lei Guo & Mark D. Krailo & Furqan Shaikh & Debor, 2023. "Integrated genomic analysis reveals aberrations in WNT signaling in germ cell tumors of childhood and adolescence," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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