IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v540y2016i7631d10.1038_nature20596.html
   My bibliography  Save this article

Genomic evolution and chemoresistance in germ-cell tumours

Author

Listed:
  • Amaro Taylor-Weiner

    (Harvard University
    Cancer Program, Broad Institute of MIT and Harvard)

  • Travis Zack

    (Harvard University
    Health Sciences and Technology, Harvard Medical School)

  • Elizabeth O’Donnell

    (Dana-Farber Cancer Institute
    Massachusetts General Hospital)

  • Jennifer L. Guerriero

    (Dana-Farber Cancer Institute)

  • Brandon Bernard

    (Dana-Farber Cancer Institute)

  • Anita Reddy

    (Harvard Medical School)

  • G. Celine Han

    (Cancer Program, Broad Institute of MIT and Harvard
    Dana-Farber Cancer Institute)

  • Saud AlDubayan

    (Boston Children’s Hospital
    King Saud bin Abdulaziz University for Health Sciences)

  • Ali Amin-Mansour

    (Cancer Program, Broad Institute of MIT and Harvard)

  • Steven E. Schumacher

    (Cancer Program, Broad Institute of MIT and Harvard)

  • Kevin Litchfield

    (The Institute of Cancer Research
    William Harvey Research Institute, Queen Mary University London)

  • Clare Turnbull

    (The Institute of Cancer Research
    William Harvey Research Institute, Queen Mary University London)

  • Stacey Gabriel

    (Cancer Program, Broad Institute of MIT and Harvard)

  • Rameen Beroukhim

    (Cancer Program, Broad Institute of MIT and Harvard
    Dana-Farber Cancer Institute)

  • Gad Getz

    (Cancer Program, Broad Institute of MIT and Harvard
    Massachusetts General Hospital)

  • Scott L. Carter

    (Cancer Program, Broad Institute of MIT and Harvard
    Center for Cancer Precision Medicine, Dana-Farber Cancer Institute
    Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA
    Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA)

  • Michelle S. Hirsch

    (Brigham and Women’s Hospital)

  • Anthony Letai

    (Dana-Farber Cancer Institute)

  • Christopher Sweeney

    (Dana-Farber Cancer Institute)

  • Eliezer M Van Allen

    (Cancer Program, Broad Institute of MIT and Harvard
    Dana-Farber Cancer Institute
    Center for Cancer Precision Medicine, Dana-Farber Cancer Institute)

Abstract

Genomic analyses show that primary germ-cell tumours are highly enriched for chromosomal reciprocal loss of heterozygosity, mutations in KRAS and have high mitochondrial priming, providing insight into chemosensitivity and the evolution of chemoresistance in this disease.

Suggested Citation

  • Amaro Taylor-Weiner & Travis Zack & Elizabeth O’Donnell & Jennifer L. Guerriero & Brandon Bernard & Anita Reddy & G. Celine Han & Saud AlDubayan & Ali Amin-Mansour & Steven E. Schumacher & Kevin Litch, 2016. "Genomic evolution and chemoresistance in germ-cell tumours," Nature, Nature, vol. 540(7631), pages 114-118, December.
    • Handle: RePEc:nat:nature:v:540:y:2016:i:7631:d:10.1038_nature20596
    DOI: 10.1038/nature20596
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature20596
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature20596?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Lin Xu & Joshua L. Pierce & Angelica Sanchez & Kenneth S. Chen & Abhay A. Shukla & Nicholas J. Fustino & Sarai H. Stuart & Aditya Bagrodia & Xue Xiao & Lei Guo & Mark D. Krailo & Furqan Shaikh & Debor, 2023. "Integrated genomic analysis reveals aberrations in WNT signaling in germ cell tumors of childhood and adolescence," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Wilfried Engl & Aliz Kunstar-Thomas & Siyi Chen & Woei Shyuan Ng & Hendrik Sielaff & Ziqing Winston Zhao, 2024. "Single-molecule imaging of SWI/SNF chromatin remodelers reveals bromodomain-mediated and cancer-mutants-specific landscape of multi-modal DNA-binding dynamics," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    3. Máire Ní Leathlobhair & Anna Frangou & Ben Kinnersley & Alex J. Cornish & Daniel Chubb & Eszter Lakatos & Prabhu Arumugam & Andreas J. Gruber & Philip Law & Avraam Tapinos & G. Maria Jakobsdottir & Il, 2024. "Genomic landscape of adult testicular germ cell tumours in the 100,000 Genomes Project," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    4. Thomas R. W. Oliver & Lia Chappell & Rashesh Sanghvi & Lauren Deighton & Naser Ansari-Pour & Stefan C. Dentro & Matthew D. Young & Tim H. H. Coorens & Hyunchul Jung & Tim Butler & Matthew D. C. Nevill, 2022. "Clonal diversification and histogenesis of malignant germ cell tumours," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:540:y:2016:i:7631:d:10.1038_nature20596. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.