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RIPK1 inhibits ZBP1-driven necroptosis during development

Author

Listed:
  • Kim Newton

    (Genentech)

  • Katherine E. Wickliffe

    (Genentech)

  • Allie Maltzman

    (Genentech)

  • Debra L. Dugger

    (Genentech)

  • Andreas Strasser

    (The Walter and Eliza Hall Institute of Medical Research
    Melbourne University)

  • Victoria C. Pham

    (Genentech)

  • Jennie R. Lill

    (Genentech)

  • Merone Roose-Girma

    (Genentech)

  • Søren Warming

    (Genentech)

  • Margaret Solon

    (Genentech)

  • Hai Ngu

    (Genentech)

  • Joshua D. Webster

    (Genentech)

  • Vishva M. Dixit

    (Genentech)

Abstract

In the absence of RIPK1, ZBP1 engages RIPK3 in a RHIM-dependent manner and acts as a critical activator of RIPK3/MLKL-dependent necroptosis.

Suggested Citation

  • Kim Newton & Katherine E. Wickliffe & Allie Maltzman & Debra L. Dugger & Andreas Strasser & Victoria C. Pham & Jennie R. Lill & Merone Roose-Girma & Søren Warming & Margaret Solon & Hai Ngu & Joshua D, 2016. "RIPK1 inhibits ZBP1-driven necroptosis during development," Nature, Nature, vol. 540(7631), pages 129-133, December.
    • Handle: RePEc:nat:nature:v:540:y:2016:i:7631:d:10.1038_nature20559
    DOI: 10.1038/nature20559
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    Cited by:

    1. Yanxiang Meng & Sarah E. Garnish & Katherine A. Davies & Katrina A. Black & Andrew P. Leis & Christopher R. Horne & Joanne M. Hildebrand & Hanadi Hoblos & Cheree Fitzgibbon & Samuel N. Young & Toby Di, 2023. "Phosphorylation-dependent pseudokinase domain dimerization drives full-length MLKL oligomerization," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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