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Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells

Author

Listed:
  • Olivier De Henau

    (Memorial Sloan Kettering Cancer Center, Parker Institute for Cancer Immunotherapy and Swim Across America/Ludwig Collaborative Laboratory)

  • Matthew Rausch

    (Infinity Pharmaceuticals, Inc.)

  • David Winkler

    (Infinity Pharmaceuticals, Inc.)

  • Luis Felipe Campesato

    (Memorial Sloan Kettering Cancer Center, Parker Institute for Cancer Immunotherapy and Swim Across America/Ludwig Collaborative Laboratory)

  • Cailian Liu

    (Memorial Sloan Kettering Cancer Center, Parker Institute for Cancer Immunotherapy and Swim Across America/Ludwig Collaborative Laboratory)

  • Daniel Hirschhorn Cymerman

    (Memorial Sloan Kettering Cancer Center, Parker Institute for Cancer Immunotherapy and Swim Across America/Ludwig Collaborative Laboratory)

  • Sadna Budhu

    (Memorial Sloan Kettering Cancer Center, Parker Institute for Cancer Immunotherapy and Swim Across America/Ludwig Collaborative Laboratory)

  • Arnab Ghosh

    (Memorial Sloan Kettering Cancer Center, Parker Institute for Cancer Immunotherapy and Swim Across America/Ludwig Collaborative Laboratory)

  • Melissa Pink

    (Infinity Pharmaceuticals, Inc.)

  • Jeremy Tchaicha

    (Infinity Pharmaceuticals, Inc.)

  • Mark Douglas

    (Infinity Pharmaceuticals, Inc.)

  • Thomas Tibbitts

    (Infinity Pharmaceuticals, Inc.)

  • Sujata Sharma

    (Infinity Pharmaceuticals, Inc.)

  • Jennifer Proctor

    (Infinity Pharmaceuticals, Inc.)

  • Nicole Kosmider

    (Infinity Pharmaceuticals, Inc.)

  • Kerry White

    (Infinity Pharmaceuticals, Inc.)

  • Howard Stern

    (Infinity Pharmaceuticals, Inc.)

  • John Soglia

    (Infinity Pharmaceuticals, Inc.)

  • Julian Adams

    (Infinity Pharmaceuticals, Inc.)

  • Vito J. Palombella

    (Infinity Pharmaceuticals, Inc.)

  • Karen McGovern

    (Infinity Pharmaceuticals, Inc.)

  • Jeffery L. Kutok

    (Infinity Pharmaceuticals, Inc.)

  • Jedd D. Wolchok

    (Memorial Sloan Kettering Cancer Center, Parker Institute for Cancer Immunotherapy and Swim Across America/Ludwig Collaborative Laboratory
    Weill Cornell Medical and Graduate Schools)

  • Taha Merghoub

    (Memorial Sloan Kettering Cancer Center, Parker Institute for Cancer Immunotherapy and Swim Across America/Ludwig Collaborative Laboratory)

Abstract

Targeting tumour-infiltrating suppressive myeloid cells with a selective PI3Kγ inhibitor overcomes resistance to checkpoint blockade therapy in various mouse myeloid-rich tumour models.

Suggested Citation

  • Olivier De Henau & Matthew Rausch & David Winkler & Luis Felipe Campesato & Cailian Liu & Daniel Hirschhorn Cymerman & Sadna Budhu & Arnab Ghosh & Melissa Pink & Jeremy Tchaicha & Mark Douglas & Thoma, 2016. "Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells," Nature, Nature, vol. 539(7629), pages 443-447, November.
    • Handle: RePEc:nat:nature:v:539:y:2016:i:7629:d:10.1038_nature20554
    DOI: 10.1038/nature20554
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    Cited by:

    1. Charlotte R. Bell & Victoria S. Pelly & Agrin Moeini & Shih-Chieh Chiang & Eimear Flanagan & Christian P. Bromley & Christopher Clark & Charles H. Earnshaw & Maria A. Koufaki & Eduardo Bonavita & Sant, 2022. "Chemotherapy-induced COX-2 upregulation by cancer cells defines their inflammatory properties and limits the efficacy of chemoimmunotherapy combinations," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Xin Guan & Liping Sun & Yuting Shen & Fengshan Jin & Xiaowan Bo & Chunyan Zhu & Xiaoxia Han & Xiaolong Li & Yu Chen & Huixiong Xu & Wenwen Yue, 2022. "Nanoparticle-enhanced radiotherapy synergizes with PD-L1 blockade to limit post-surgical cancer recurrence and metastasis," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Yonghyun Lee & Jongyoon Shinn & Cheng Xu & Hannah E. Dobson & Nouri Neamati & James J. Moon, 2023. "Hyaluronic acid-bilirubin nanomedicine-based combination chemoimmunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    4. Lei Zhang & Li Jiang & Liang Yu & Qin Li & Xiangjun Tian & Jingquan He & Ling Zeng & Yuqin Yang & Chaoran Wang & Yuhan Wei & Xiaoyue Jiang & Jing Li & Xiaolu Ge & Qisheng Gu & Jikun Li & Di Wu & Antho, 2022. "Inhibition of UBA6 by inosine augments tumour immunogenicity and responses," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    5. Mingming Zhao & Xiaohui Cheng & Pingwen Shao & Yao Dong & Yongjie Wu & Lin Xiao & Zhiying Cui & Xuedi Sun & Chuancheng Gao & Jiangning Chen & Zhen Huang & Junfeng Zhang, 2024. "Bacterial protoplast-derived nanovesicles carrying CRISPR-Cas9 tools re-educate tumor-associated macrophages for enhanced cancer immunotherapy," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    6. Fengqiao Li & Xue-Qing Zhang & William Ho & Maoping Tang & Zhongyu Li & Lei Bu & Xiaoyang Xu, 2023. "mRNA lipid nanoparticle-mediated pyroptosis sensitizes immunologically cold tumors to checkpoint immunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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