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PI3Kγ is a molecular switch that controls immune suppression

Author

Listed:
  • Megan M. Kaneda

    (Moores Cancer Center, University of California, San Diego)

  • Karen S. Messer

    (Moores Cancer Center, University of California, San Diego
    Department of Family Medicine and Public Health University of California, San Diego)

  • Natacha Ralainirina

    (Moores Cancer Center, University of California, San Diego)

  • Hongying Li

    (Moores Cancer Center, University of California, San Diego
    Department of Family Medicine and Public Health University of California, San Diego)

  • Christopher J. Leem

    (Moores Cancer Center, University of California, San Diego)

  • Sara Gorjestani

    (Moores Cancer Center, University of California, San Diego)

  • Gyunghwi Woo

    (Moores Cancer Center, University of California, San Diego)

  • Abraham V. Nguyen

    (Moores Cancer Center, University of California, San Diego)

  • Camila C. Figueiredo

    (Moores Cancer Center, University of California, San Diego
    Dep. Biologia Celular, UERJ)

  • Philippe Foubert

    (Moores Cancer Center, University of California, San Diego)

  • Michael C. Schmid

    (Moores Cancer Center, University of California, San Diego)

  • Melissa Pink

    (Infinity Pharmaceuticals)

  • David G. Winkler

    (Infinity Pharmaceuticals)

  • Matthew Rausch

    (Infinity Pharmaceuticals)

  • Vito J. Palombella

    (Infinity Pharmaceuticals)

  • Jeffery Kutok

    (Infinity Pharmaceuticals)

  • Karen McGovern

    (Infinity Pharmaceuticals)

  • Kelly A. Frazer

    (University of California, San Diego
    Institute for Genomic Medicine, University of California, San Diego)

  • Xuefeng Wu

    (University of California, San Diego)

  • Michael Karin

    (University of California, San Diego)

  • Roman Sasik

    (Center for Computational Biology and Bioinformatics, Institute for Genomic Medicine, University of California, San Diego)

  • Ezra E. W. Cohen

    (Moores Cancer Center, University of California, San Diego
    University of California, San Diego)

  • Judith A. Varner

    (Moores Cancer Center, University of California, San Diego
    University of California, San Diego
    University of California, San Diego)

Abstract

Modulation of PI3Kγ activity regulates macrophage polarization during inflammation and cancer, whilst combining PI3Kγ inhibition with immune checkpoint inhibitors leads to synergistic tumour-inhibitory effects.

Suggested Citation

  • Megan M. Kaneda & Karen S. Messer & Natacha Ralainirina & Hongying Li & Christopher J. Leem & Sara Gorjestani & Gyunghwi Woo & Abraham V. Nguyen & Camila C. Figueiredo & Philippe Foubert & Michael C. , 2016. "PI3Kγ is a molecular switch that controls immune suppression," Nature, Nature, vol. 539(7629), pages 437-442, November.
    • Handle: RePEc:nat:nature:v:539:y:2016:i:7629:d:10.1038_nature19834
    DOI: 10.1038/nature19834
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    Citations

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    Cited by:

    1. Erik Nutma & Nurun Fancy & Maria Weinert & Stergios Tsartsalis & Manuel C. Marzin & Robert C. J. Muirhead & Irene Falk & Marjolein Breur & Joy Bruin & David Hollaus & Robin Pieterman & Jasper Anink & , 2023. "Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases," Nature Communications, Nature, vol. 14(1), pages 1-25, December.
    2. Michael C. Schmid & Sang Won Kang & Hui Chen & Marc Paradise & Anghesom Ghebremedhin & Megan M. Kaneda & Shao-Ming Chin & Anh Do & D. Martin Watterson & Judith A. Varner, 2022. "PI3Kγ stimulates a high molecular weight form of myosin light chain kinase to promote myeloid cell adhesion and tumor inflammation," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    3. Mingming Zhao & Xiaohui Cheng & Pingwen Shao & Yao Dong & Yongjie Wu & Lin Xiao & Zhiying Cui & Xuedi Sun & Chuancheng Gao & Jiangning Chen & Zhen Huang & Junfeng Zhang, 2024. "Bacterial protoplast-derived nanovesicles carrying CRISPR-Cas9 tools re-educate tumor-associated macrophages for enhanced cancer immunotherapy," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    4. Michael Moret & Irene Pachon Angona & Leandro Cotos & Shen Yan & Kenneth Atz & Cyrill Brunner & Martin Baumgartner & Francesca Grisoni & Gisbert Schneider, 2023. "Leveraging molecular structure and bioactivity with chemical language models for de novo drug design," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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