IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v539y2016i7628d10.1038_nature20104.html
   My bibliography  Save this article

Reconstitution in vitro of the entire cycle of the mouse female germ line

Author

Listed:
  • Orie Hikabe

    (Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1)

  • Nobuhiko Hamazaki

    (Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1)

  • Go Nagamatsu

    (Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1)

  • Yayoi Obata

    (Tokyo University of Agriculture, 1-1-1, Sakuragaoka)

  • Yuji Hirao

    (NARO Institute of Livestock and Grassland Science)

  • Norio Hamada

    (Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1
    Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1)

  • So Shimamoto

    (Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1)

  • Takuya Imamura

    (Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1)

  • Kinichi Nakashima

    (Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1)

  • Mitinori Saitou

    (Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho
    Center for iPS Cell Research and Application, Kyoto University, 53 Kawahara-cho, Shogoin
    Institute for Integrated Cell-Material Sciences, Kyoto University, Yoshida-Ushinomiya-cho
    JST, ERATO, Yoshida-Konoe-cho)

  • Katsuhiko Hayashi

    (Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1
    JST, PRESTO, Maidashi 3-1-1)

Abstract

Using a protocol that recapitulates both meiosis and oocyte growth in vitro, the authors induce mouse pluripotent stem cells to differentiate into fully functional oocytes that can be fertilized and generate viable offspring, thereby recapitulating the full mammalian female germline cycle in a dish.

Suggested Citation

  • Orie Hikabe & Nobuhiko Hamazaki & Go Nagamatsu & Yayoi Obata & Yuji Hirao & Norio Hamada & So Shimamoto & Takuya Imamura & Kinichi Nakashima & Mitinori Saitou & Katsuhiko Hayashi, 2016. "Reconstitution in vitro of the entire cycle of the mouse female germ line," Nature, Nature, vol. 539(7628), pages 299-303, November.
    • Handle: RePEc:nat:nature:v:539:y:2016:i:7628:d:10.1038_nature20104
    DOI: 10.1038/nature20104
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature20104
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature20104?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Yusheng Liu & Wenrong Tao & Shuang Wu & Yiwei Zhang & Hu Nie & Zhenzhen Hou & Jingye Zhang & Zhen Yang & Zi-Jiang Chen & Jiaqiang Wang & Falong Lu & Keliang Wu, 2024. "Maternal mRNA deadenylation is defective in in vitro matured mouse and human oocytes," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:539:y:2016:i:7628:d:10.1038_nature20104. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.