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T-cell acute leukaemia exhibits dynamic interactions with bone marrow microenvironments

Author

Listed:
  • Edwin D. Hawkins

    (Sir Alexander Fleming Building, Imperial College London
    The Walter and Eliza Hall Institute of Medical Research
    The University of Melbourne)

  • Delfim Duarte

    (Sir Alexander Fleming Building, Imperial College London
    The Francis Crick Institute)

  • Olufolake Akinduro

    (Sir Alexander Fleming Building, Imperial College London)

  • Reema A. Khorshed

    (Sir Alexander Fleming Building, Imperial College London)

  • Diana Passaro

    (The Francis Crick Institute, Haematopoietic Stem Cell Laboratory)

  • Malgorzata Nowicka

    (SIB Swiss Institute of Bioinformatics and Institute of Molecular Life Sciences, University of Zurich)

  • Lenny Straszkowski

    (Stem Cell Regulation Unit, St Vincent’s Institute of Medical Research)

  • Mark K. Scott

    (Sir Alexander Fleming Building, Imperial College London
    The Walter and Eliza Hall Institute of Medical Research)

  • Steve Rothery

    (Imperial College Facility for Imaging by Light Microscopy, Sir Alexander Fleming Building, Imperial College London)

  • Nicola Ruivo

    (Sir Alexander Fleming Building, Imperial College London)

  • Katie Foster

    (The Francis Crick Institute, Haematopoietic Stem Cell Laboratory)

  • Michaela Waibel

    (University of Melbourne
    Peter MacCallum Cancer Centre)

  • Ricky W. Johnstone

    (University of Melbourne
    Peter MacCallum Cancer Centre)

  • Simon J. Harrison

    (University of Melbourne
    Peter MacCallum Cancer Centre)

  • David A. Westerman

    (University of Melbourne
    Peter MacCallum Cancer Centre)

  • Hang Quach

    (St Vincent’s Hospital
    The University of Melbourne)

  • John Gribben

    (Centre of Haemato-Oncology, Cancer Research UK Clinical Centre, Barts Cancer Institute, St Bartholomew’s Hospital, Queen Mary University of London)

  • Mark D. Robinson

    (SIB Swiss Institute of Bioinformatics and Institute of Molecular Life Sciences, University of Zurich)

  • Louise E. Purton

    (Stem Cell Regulation Unit, St Vincent’s Institute of Medical Research
    The University of Melbourne)

  • Dominique Bonnet

    (The Francis Crick Institute, Haematopoietic Stem Cell Laboratory)

  • Cristina Lo Celso

    (Sir Alexander Fleming Building, Imperial College London
    The Francis Crick Institute)

Abstract

Here, leukaemia cells are followed by intravital microscopy as they infiltrate mouse bone marrow and respond to chemotherapy, revealing that at all stages analysed they are highly motile and do not display any associations with particular bone marrow sub-compartments.

Suggested Citation

  • Edwin D. Hawkins & Delfim Duarte & Olufolake Akinduro & Reema A. Khorshed & Diana Passaro & Malgorzata Nowicka & Lenny Straszkowski & Mark K. Scott & Steve Rothery & Nicola Ruivo & Katie Foster & Mich, 2016. "T-cell acute leukaemia exhibits dynamic interactions with bone marrow microenvironments," Nature, Nature, vol. 538(7626), pages 518-522, October.
    • Handle: RePEc:nat:nature:v:538:y:2016:i:7626:d:10.1038_nature19801
    DOI: 10.1038/nature19801
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    Cited by:

    1. Georgia K. Atkin-Smith & Jascinta P. Santavanond & Amanda Light & Joel S. Rimes & Andre L. Samson & Jeremy Er & Joy Liu & Darryl N. Johnson & Mélanie Le Page & Pradeep Rajasekhar & Raymond K. H. Yip &, 2024. "In situ visualization of endothelial cell-derived extracellular vesicle formation in steady state and malignant conditions," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Raymond K. H. Yip & Joel S. Rimes & Bianca D. Capaldo & François Vaillant & Kellie A. Mouchemore & Bhupinder Pal & Yunshun Chen & Elliot Surgenor & Andrew J. Murphy & Robin L. Anderson & Gordon K. Smy, 2021. "Mammary tumour cells remodel the bone marrow vascular microenvironment to support metastasis," Nature Communications, Nature, vol. 12(1), pages 1-17, December.

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