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The epichaperome is an integrated chaperome network that facilitates tumour survival

Author

Listed:
  • Anna Rodina

    (Program in Chemical Biology, Sloan Kettering Institute)

  • Tai Wang

    (Program in Chemical Biology, Sloan Kettering Institute)

  • Pengrong Yan

    (Program in Chemical Biology, Sloan Kettering Institute)

  • Erica DaGama Gomes

    (Program in Chemical Biology, Sloan Kettering Institute)

  • Mark P. S. Dunphy

    (Memorial Sloan Kettering Cancer Center)

  • Nagavarakishore Pillarsetty

    (Memorial Sloan Kettering Cancer Center)

  • John Koren

    (Program in Chemical Biology, Sloan Kettering Institute)

  • John F. Gerecitano

    (Lymphoma Service, Memorial Sloan Kettering Cancer Center)

  • Tony Taldone

    (Program in Chemical Biology, Sloan Kettering Institute)

  • Hongliang Zong

    (Haematology and Medical Oncology, Weill Cornell Medical College)

  • Eloisi Caldas-Lopes

    (Program in Chemical Biology, Sloan Kettering Institute)

  • Mary Alpaugh

    (Program in Chemical Biology, Sloan Kettering Institute
    †Present address: Department of Biology and Department of Biomedical and Translational Sciences, Rowan University, Glassborro, New Jersey 08028, USA.)

  • Adriana Corben

    (Memorial Sloan Kettering Cancer Center)

  • Matthew Riolo

    (Program in Chemical Biology, Sloan Kettering Institute)

  • Brad Beattie

    (Memorial Sloan Kettering Cancer Center)

  • Christina Pressl

    (Memorial Sloan Kettering Cancer Center)

  • Radu I. Peter

    (Technical University of Cluj-Napoca)

  • Chao Xu

    (Program in Chemical Biology, Sloan Kettering Institute)

  • Robert Trondl

    (Program in Chemical Biology, Sloan Kettering Institute)

  • Hardik J. Patel

    (Program in Chemical Biology, Sloan Kettering Institute)

  • Fumiko Shimizu

    (Program in Chemical Biology, Sloan Kettering Institute)

  • Alexander Bolaender

    (Program in Chemical Biology, Sloan Kettering Institute)

  • Chenghua Yang

    (Program in Chemical Biology, Sloan Kettering Institute)

  • Palak Panchal

    (Program in Chemical Biology, Sloan Kettering Institute)

  • Mohammad F. Farooq

    (Molecular, Cellular & Biomedical Sciences, University of New Hampshire)

  • Sarah Kishinevsky

    (Program in Chemical Biology, Sloan Kettering Institute)

  • Shanu Modi

    (Breast Cancer Service, Memorial Sloan Kettering Cancer Center)

  • Oscar Lin

    (Memorial Sloan Kettering Cancer Center)

  • Feixia Chu

    (Molecular, Cellular & Biomedical Sciences, University of New Hampshire)

  • Sujata Patil

    (Memorial Sloan Kettering Cancer Center)

  • Hediye Erdjument-Bromage

    (Microchemistry and Proteomics Core, Molecular Biology Program, Memorial Sloan Kettering Cancer Center)

  • Pat Zanzonico

    (Memorial Sloan Kettering Cancer Center)

  • Clifford Hudis

    (Breast Cancer Service, Memorial Sloan Kettering Cancer Center)

  • Lorenz Studer

    (Developmental Biology Program, Memorial Sloan Kettering Cancer Center)

  • Gail J. Roboz

    (Haematology and Medical Oncology, Weill Cornell Medical College)

  • Ethel Cesarman

    (Haematology and Medical Oncology, Weill Cornell Medical College)

  • Leandro Cerchietti

    (Haematology and Medical Oncology, Weill Cornell Medical College)

  • Ross Levine

    (Human Oncology and Pathogenesis Program, Sloan Kettering Institute)

  • Ari Melnick

    (Haematology and Medical Oncology, Weill Cornell Medical College)

  • Steven M. Larson

    (Memorial Sloan Kettering Cancer Center)

  • Jason S. Lewis

    (Memorial Sloan Kettering Cancer Center)

  • Monica L. Guzman

    (Haematology and Medical Oncology, Weill Cornell Medical College)

  • Gabriela Chiosis

    (Program in Chemical Biology, Sloan Kettering Institute
    Breast Cancer Service, Memorial Sloan Kettering Cancer Center)

Abstract

Chaperomes are dynamic assemblies of proteins that regulate cellular homeostasis but specific cellular stresses remodel chaperome components into a stable chaperome network called the epichaperome, which might offer a new cancer target.

Suggested Citation

  • Anna Rodina & Tai Wang & Pengrong Yan & Erica DaGama Gomes & Mark P. S. Dunphy & Nagavarakishore Pillarsetty & John Koren & John F. Gerecitano & Tony Taldone & Hongliang Zong & Eloisi Caldas-Lopes & M, 2016. "The epichaperome is an integrated chaperome network that facilitates tumour survival," Nature, Nature, vol. 538(7625), pages 397-401, October.
    • Handle: RePEc:nat:nature:v:538:y:2016:i:7625:d:10.1038_nature19807
    DOI: 10.1038/nature19807
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    Citations

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    Cited by:

    1. Florisela Herrejon Chavez & Hanzhi Luo & Paolo Cifani & Alli Pine & Eren L. Chu & Suhasini Joshi & Ersilia Barin & Alexandra Schurer & Mandy Chan & Kathryn Chang & Grace Y. Q. Han & Aspen J. Pierson &, 2023. "RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    2. Kaushik Bhattacharya & Samarpan Maiti & Szabolcs Zahoran & Lorenz Weidenauer & Dina Hany & Diana Wider & Lilia Bernasconi & Manfredo Quadroni & Martine Collart & Didier Picard, 2022. "Translational reprogramming in response to accumulating stressors ensures critical threshold levels of Hsp90 for mammalian life," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Mark R. Woodford & Dimitra Bourboulia & Mehdi Mollapour, 2023. "Epichaperomics reveals dysfunctional chaperone protein networks," Nature Communications, Nature, vol. 14(1), pages 1-3, December.
    4. Hannah Drew Rickner & Lulu Jiang & Rui Hong & Nicholas K. O’Neill & Chromewell A. Mojica & Benjamin J. Snyder & Lushuang Zhang & Dipan Shaw & Maria Medalla & Benjamin Wolozin & Christine S. Cheng, 2022. "Single cell transcriptomic profiling of a neuron-astrocyte assembloid tauopathy model," Nature Communications, Nature, vol. 13(1), pages 1-22, December.
    5. Anna Rodina & Chao Xu & Chander S. Digwal & Suhasini Joshi & Yogita Patel & Anand R. Santhaseela & Sadik Bay & Swathi Merugu & Aftab Alam & Pengrong Yan & Chenghua Yang & Tanaya Roychowdhury & Palak P, 2023. "Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation," Nature Communications, Nature, vol. 14(1), pages 1-26, December.
    6. Tanaya Roychowdhury & Seth W. McNutt & Chiranjeevi Pasala & Hieu T. Nguyen & Daniel T. Thornton & Sahil Sharma & Luke Botticelli & Chander S. Digwal & Suhasini Joshi & Nan Yang & Palak Panchal & Soupa, 2024. "Phosphorylation-driven epichaperome assembly is a regulator of cellular adaptability and proliferation," Nature Communications, Nature, vol. 15(1), pages 1-28, December.

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