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Epichaperomics reveals dysfunctional chaperone protein networks

Author

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  • Mark R. Woodford

    (SUNY Upstate Medical University
    SUNY Upstate Medical University
    SUNY Upstate Medical University)

  • Dimitra Bourboulia

    (SUNY Upstate Medical University
    SUNY Upstate Medical University
    SUNY Upstate Medical University)

  • Mehdi Mollapour

    (SUNY Upstate Medical University
    SUNY Upstate Medical University
    SUNY Upstate Medical University)

Abstract

Molecular chaperones establish essential protein-protein interaction networks. Modified versions of these assemblies are generally enriched in certain maladies. A study published in Nature Communications used epichaperomics to identify unique changes occurring in chaperone-formed protein networks during mitosis in cancer cells.

Suggested Citation

  • Mark R. Woodford & Dimitra Bourboulia & Mehdi Mollapour, 2023. "Epichaperomics reveals dysfunctional chaperone protein networks," Nature Communications, Nature, vol. 14(1), pages 1-3, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-40713-z
    DOI: 10.1038/s41467-023-40713-z
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    References listed on IDEAS

    as
    1. Anna Rodina & Chao Xu & Chander S. Digwal & Suhasini Joshi & Yogita Patel & Anand R. Santhaseela & Sadik Bay & Swathi Merugu & Aftab Alam & Pengrong Yan & Chenghua Yang & Tanaya Roychowdhury & Palak P, 2023. "Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation," Nature Communications, Nature, vol. 14(1), pages 1-26, December.
    2. Anna Rodina & Tai Wang & Pengrong Yan & Erica DaGama Gomes & Mark P. S. Dunphy & Nagavarakishore Pillarsetty & John Koren & John F. Gerecitano & Tony Taldone & Hongliang Zong & Eloisi Caldas-Lopes & M, 2016. "The epichaperome is an integrated chaperome network that facilitates tumour survival," Nature, Nature, vol. 538(7625), pages 397-401, October.
    3. Adeela Kamal & Lia Thao & John Sensintaffar & Lin Zhang & Marcus F. Boehm & Lawrence C. Fritz & Francis J. Burrows, 2003. "A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors," Nature, Nature, vol. 425(6956), pages 407-410, September.
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