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Tissue-specific mutation accumulation in human adult stem cells during life

Author

Listed:
  • Francis Blokzijl

    (Center for Molecular Medicine, Cancer Genomics Netherlands, University Medical Center Utrecht
    Hubrecht Institute for Developmental Biology and Stem Cell Research, KNAW and University Medical Center Utrecht)

  • Joep de Ligt

    (Center for Molecular Medicine, Cancer Genomics Netherlands, University Medical Center Utrecht
    Hubrecht Institute for Developmental Biology and Stem Cell Research, KNAW and University Medical Center Utrecht)

  • Myrthe Jager

    (Center for Molecular Medicine, Cancer Genomics Netherlands, University Medical Center Utrecht
    Hubrecht Institute for Developmental Biology and Stem Cell Research, KNAW and University Medical Center Utrecht)

  • Valentina Sasselli

    (Hubrecht Institute for Developmental Biology and Stem Cell Research, KNAW and University Medical Center Utrecht)

  • Sophie Roerink

    (Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus)

  • Nobuo Sasaki

    (Hubrecht Institute for Developmental Biology and Stem Cell Research, KNAW and University Medical Center Utrecht)

  • Meritxell Huch

    (Hubrecht Institute for Developmental Biology and Stem Cell Research, KNAW and University Medical Center Utrecht)

  • Sander Boymans

    (Center for Molecular Medicine, Cancer Genomics Netherlands, University Medical Center Utrecht
    Hubrecht Institute for Developmental Biology and Stem Cell Research, KNAW and University Medical Center Utrecht)

  • Ewart Kuijk

    (Center for Molecular Medicine, Cancer Genomics Netherlands, University Medical Center Utrecht
    Hubrecht Institute for Developmental Biology and Stem Cell Research, KNAW and University Medical Center Utrecht)

  • Pjotr Prins

    (Hubrecht Institute for Developmental Biology and Stem Cell Research, KNAW and University Medical Center Utrecht)

  • Isaac J. Nijman

    (Hubrecht Institute for Developmental Biology and Stem Cell Research, KNAW and University Medical Center Utrecht)

  • Inigo Martincorena

    (Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus)

  • Michal Mokry

    (University Medical Center Utrecht)

  • Caroline L. Wiegerinck

    (University Medical Center Utrecht)

  • Sabine Middendorp

    (University Medical Center Utrecht)

  • Toshiro Sato

    (Hubrecht Institute for Developmental Biology and Stem Cell Research, KNAW and University Medical Center Utrecht)

  • Gerald Schwank

    (Hubrecht Institute for Developmental Biology and Stem Cell Research, KNAW and University Medical Center Utrecht)

  • Edward E. S. Nieuwenhuis

    (University Medical Center Utrecht)

  • Monique M. A. Verstegen

    (Erasmus MC-University Medical Center)

  • Luc J. W. van der Laan

    (Erasmus MC-University Medical Center)

  • Jeroen de Jonge

    (Erasmus MC-University Medical Center)

  • Jan N. M. IJzermans

    (Erasmus MC-University Medical Center)

  • Robert G. Vries

    (Foundation Hubrecht Organoid Technology (HUB))

  • Marc van de Wetering

    (Hubrecht Institute for Developmental Biology and Stem Cell Research, KNAW and University Medical Center Utrecht)

  • Michael R. Stratton

    (Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus)

  • Hans Clevers

    (Hubrecht Institute for Developmental Biology and Stem Cell Research, KNAW and University Medical Center Utrecht)

  • Edwin Cuppen

    (Center for Molecular Medicine, Cancer Genomics Netherlands, University Medical Center Utrecht
    Hubrecht Institute for Developmental Biology and Stem Cell Research, KNAW and University Medical Center Utrecht)

  • Ruben van Boxtel

    (Center for Molecular Medicine, Cancer Genomics Netherlands, University Medical Center Utrecht
    Hubrecht Institute for Developmental Biology and Stem Cell Research, KNAW and University Medical Center Utrecht)

Abstract

Stem cells of the liver, colon and small intestine gradually accumulate mutations throughout life at a similar rate even though cancer incidence varies greatly among these tissues.

Suggested Citation

  • Francis Blokzijl & Joep de Ligt & Myrthe Jager & Valentina Sasselli & Sophie Roerink & Nobuo Sasaki & Meritxell Huch & Sander Boymans & Ewart Kuijk & Pjotr Prins & Isaac J. Nijman & Inigo Martincorena, 2016. "Tissue-specific mutation accumulation in human adult stem cells during life," Nature, Nature, vol. 538(7624), pages 260-264, October.
    • Handle: RePEc:nat:nature:v:538:y:2016:i:7624:d:10.1038_nature19768
    DOI: 10.1038/nature19768
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    Citations

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    Cited by:

    1. Eline J. M. Bertrums & Jurrian K. Kanter & Lucca L. M. Derks & Mark Verheul & Laurianne Trabut & Markus J. Roosmalen & Henrik Hasle & Evangelia Antoniou & Dirk Reinhardt & Michael N. Dworzak & Nora Mü, 2024. "Selective pressures of platinum compounds shape the evolution of therapy-related myeloid neoplasms," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Ewart Kuijk & Onno Kranenburg & Edwin Cuppen & Arne Van Hoeck, 2022. "Common anti-cancer therapies induce somatic mutations in stem cells of healthy tissue," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    3. Shamir Montazid & Sheila Bandyopadhyay & Daniel W. Hart & Nan Gao & Brian Johnson & Sri G. Thrumurthy & Dustin J. Penn & Bettina Wernisch & Mukesh Bansal & Philipp M. Altrock & Fabian Rost & Patrycja , 2023. "Adult stem cell activity in naked mole rats for long-term tissue maintenance," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    4. Giulia Schiroli & Vinay Kartha & Fabiana M. Duarte & Trine A. Kristiansen & Christina Mayerhofer & Rojesh Shrestha & Andrew Earl & Yan Hu & Tristan Tay & Catherine Rhee & Jason D. Buenrostro & David T, 2024. "Cell of origin epigenetic priming determines susceptibility to Tet2 mutation," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    5. Eun Seop Seo & Ji Won Lee & Jinyeong Lim & Sunghwan Shin & Hee Won Cho & Hee Young Ju & Keon Hee Yoo & Ki Woong Sung & Woong-Yang Park, 2024. "Germline functional variants contribute to somatic mutation and outcomes in neuroblastoma," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    6. Bernard C. H. Lee & Philip S. Robinson & Tim H. H. Coorens & Helen H. N. Yan & Sigurgeir Olafsson & Henry Lee-Six & Mathijs A. Sanders & Hoi Cheong Siu & James Hewinson & Sarah S. K. Yue & Wai Yin Tsu, 2022. "Mutational landscape of normal epithelial cells in Lynch Syndrome patients," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    7. Biancastella Cereser & Angela Yiu & Neha Tabassum & Lisa Del Bel Belluz & Sladjana Zagorac & Kenneth Russell Zapanta Ancheta & Rongrong Zhong & Cristian Miere & Alicia Rose Jeffries-Jones & Nina Moder, 2023. "The mutational landscape of the adult healthy parous and nulliparous human breast," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    8. Rotem Katzir & Noam Rudberg & Keren Yizhak, 2022. "Estimating tumor mutational burden from RNA-sequencing without a matched-normal sample," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    9. Maarten H. Geurts & Shashank Gandhi & Matteo G. Boretto & Ninouk Akkerman & Lucca L. M. Derks & Gijs Son & Martina Celotti & Sarina Harshuk-Shabso & Flavia Peci & Harry Begthel & Delilah Hendriks & Pa, 2023. "One-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    10. Philip S. Robinson & Laura E. Thomas & Federico Abascal & Hyunchul Jung & Luke M. R. Harvey & Hannah D. West & Sigurgeir Olafsson & Bernard C. H. Lee & Tim H. H. Coorens & Henry Lee-Six & Laura Butlin, 2022. "Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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