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The lipolysis pathway sustains normal and transformed stem cells in adult Drosophila

Author

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  • Shree Ram Singh

    (The Basic Research Laboratory, National Cancer Institute at Frederick, National Institutes of Health)

  • Xiankun Zeng

    (The Basic Research Laboratory, National Cancer Institute at Frederick, National Institutes of Health)

  • Jiangsha Zhao

    (The Basic Research Laboratory, National Cancer Institute at Frederick, National Institutes of Health)

  • Ying Liu

    (The Basic Research Laboratory, National Cancer Institute at Frederick, National Institutes of Health)

  • Gerald Hou

    (The Basic Research Laboratory, National Cancer Institute at Frederick, National Institutes of Health)

  • Hanhan Liu

    (The Basic Research Laboratory, National Cancer Institute at Frederick, National Institutes of Health)

  • Steven X. Hou

    (The Basic Research Laboratory, National Cancer Institute at Frederick, National Institutes of Health)

Abstract

Attenuating the lipolysis pathway in Drosophila melanogaster by modulation of the COP1–Arf1 signalling complex induced necrosis in stem cells and led to their engulfment by differentiated cells.

Suggested Citation

  • Shree Ram Singh & Xiankun Zeng & Jiangsha Zhao & Ying Liu & Gerald Hou & Hanhan Liu & Steven X. Hou, 2016. "The lipolysis pathway sustains normal and transformed stem cells in adult Drosophila," Nature, Nature, vol. 538(7623), pages 109-113, October.
  • Handle: RePEc:nat:nature:v:538:y:2016:i:7623:d:10.1038_nature19788
    DOI: 10.1038/nature19788
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    Cited by:

    1. Lily L. Wong & Christina G. Bruxvoort & Nicholas I. Cejda & Matthew R. Delaney & Jannette Rodriguez Otero & David J. Forsthoefel, 2022. "Intestine-enriched apolipoprotein b orthologs are required for stem cell progeny differentiation and regeneration in planarians," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    2. Lifan Chen & Zisheng Fan & Jie Chang & Ruirui Yang & Hui Hou & Hao Guo & Yinghui Zhang & Tianbiao Yang & Chenmao Zhou & Qibang Sui & Zhengyang Chen & Chen Zheng & Xinyue Hao & Keke Zhang & Rongrong Cu, 2023. "Sequence-based drug design as a concept in computational drug design," Nature Communications, Nature, vol. 14(1), pages 1-21, December.

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