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Accessory subunits are integral for assembly and function of human mitochondrial complex I

Author

Listed:
  • David A. Stroud

    (Monash Biomedicine Discovery Institute, Monash University)

  • Elliot E. Surgenor

    (Monash Biomedicine Discovery Institute, Monash University)

  • Luke E. Formosa

    (Monash Biomedicine Discovery Institute, Monash University
    La Trobe Institute for Molecular Science, La Trobe University)

  • Boris Reljic

    (La Trobe Institute for Molecular Science, La Trobe University
    †Present address: Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria 3052, Australia.)

  • Ann E. Frazier

    (Murdoch Childrens Research Institute, Royal Children’s Hospital
    University of Melbourne)

  • Marris G. Dibley

    (Monash Biomedicine Discovery Institute, Monash University)

  • Laura D. Osellame

    (Monash Biomedicine Discovery Institute, Monash University)

  • Tegan Stait

    (Murdoch Childrens Research Institute, Royal Children’s Hospital)

  • Traude H. Beilharz

    (Monash Biomedicine Discovery Institute, Monash University)

  • David R. Thorburn

    (Murdoch Childrens Research Institute, Royal Children’s Hospital
    University of Melbourne
    Victorian Clinical Genetics Services, Royal Children’s Hospital)

  • Agus Salim

    (La Trobe University)

  • Michael T. Ryan

    (Monash Biomedicine Discovery Institute, Monash University)

Abstract

Gene-editing technology and large-scale proteomics are used to provide insights into the modular assembly of the human mitochondrial respiratory chain complex I, as well as identifying new assembly factors.

Suggested Citation

  • David A. Stroud & Elliot E. Surgenor & Luke E. Formosa & Boris Reljic & Ann E. Frazier & Marris G. Dibley & Laura D. Osellame & Tegan Stait & Traude H. Beilharz & David R. Thorburn & Agus Salim & Mich, 2016. "Accessory subunits are integral for assembly and function of human mitochondrial complex I," Nature, Nature, vol. 538(7623), pages 123-126, October.
    • Handle: RePEc:nat:nature:v:538:y:2016:i:7623:d:10.1038_nature19754
    DOI: 10.1038/nature19754
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    Cited by:

    1. Irene H. Flønes & Lilah Toker & Dagny Ann Sandnes & Martina Castelli & Sepideh Mostafavi & Njål Lura & Omnia Shadad & Erika Fernandez-Vizarra & Cèlia Painous & Alexandra Pérez-Soriano & Yaroslau Compt, 2024. "Mitochondrial complex I deficiency stratifies idiopathic Parkinson’s disease," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Cesare Granata & Nikeisha J. Caruana & Javier Botella & Nicholas A. Jamnick & Kevin Huynh & Jujiao Kuang & Hans A. Janssen & Boris Reljic & Natalie A. Mellett & Adrienne Laskowski & Tegan L. Stait & A, 2021. "High-intensity training induces non-stoichiometric changes in the mitochondrial proteome of human skeletal muscle without reorganisation of respiratory chain content," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    3. Enrique Balderas & David R. Eberhardt & Sandra Lee & John M. Pleinis & Salah Sommakia & Anthony M. Balynas & Xue Yin & Mitchell C. Parker & Colin T. Maguire & Scott Cho & Marta W. Szulik & Anna Bakhti, 2022. "Mitochondrial calcium uniporter stabilization preserves energetic homeostasis during Complex I impairment," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    4. Blanca Jiménez-Gómez & Patricia Ortega-Sáenz & Lin Gao & Patricia González-Rodríguez & Paula García-Flores & Navdeep Chandel & José López-Barneo, 2023. "Transgenic NADH dehydrogenase restores oxygen regulation of breathing in mitochondrial complex I-deficient mice," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    5. Zhaoxiang He & Mengchen Wu & Hongtao Tian & Liangdong Wang & Yiqi Hu & Fangzhu Han & Jiancang Zhou & Yong Wang & Long Zhou, 2024. "Euglena’s atypical respiratory chain adapts to the discoidal cristae and flexible metabolism," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    6. Yuwan Chen & Wen Zhou & Yufei Xia & Weijie Zhang & Qun Zhao & Xinwei Li & Hang Gao & Zhen Liang & Guanghui Ma & Kaiguang Yang & Lihua Zhang & Yukui Zhang, 2023. "Targeted cross-linker delivery for the in situ mapping of protein conformations and interactions in mitochondria," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    7. Minji Kim & Remigiusz A. Serwa & Lukasz Samluk & Ida Suppanz & Agata Kodroń & Tomasz M. Stępkowski & Praveenraj Elancheliyan & Biniyam Tsegaye & Silke Oeljeklaus & Michal Wasilewski & Bettina Warschei, 2023. "Immunoproteasome-specific subunit PSMB9 induction is required to regulate cellular proteostasis upon mitochondrial dysfunction," Nature Communications, Nature, vol. 14(1), pages 1-23, December.

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