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Single-cell analysis of mixed-lineage states leading to a binary cell fate choice

Author

Listed:
  • Andre Olsson

    (Cincinnati Children’s Hospital Medical Center)

  • Meenakshi Venkatasubramanian

    (Cincinnati Children’s Hospital Medical Center)

  • Viren K. Chaudhri

    (Cincinnati Children’s Hospital Medical Center)

  • Bruce J. Aronow

    (Cincinnati Children’s Hospital Medical Center)

  • Nathan Salomonis

    (Cincinnati Children’s Hospital Medical Center)

  • Harinder Singh

    (Cincinnati Children’s Hospital Medical Center)

  • H. Leighton Grimes

    (Cincinnati Children’s Hospital Medical Center
    Cincinnati Children’s Hospital Medical Center)

Abstract

Stem cells generate progenitors that transition through a series of dynamically unstable states with mixed-lineage gene expression, culminating in the specification of cell-fate.

Suggested Citation

  • Andre Olsson & Meenakshi Venkatasubramanian & Viren K. Chaudhri & Bruce J. Aronow & Nathan Salomonis & Harinder Singh & H. Leighton Grimes, 2016. "Single-cell analysis of mixed-lineage states leading to a binary cell fate choice," Nature, Nature, vol. 537(7622), pages 698-702, September.
    • Handle: RePEc:nat:nature:v:537:y:2016:i:7622:d:10.1038_nature19348
    DOI: 10.1038/nature19348
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    Citations

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    Cited by:

    1. Yoshihiro Hayashi & Yasushige Kamimura-Aoyagi & Sayuri Nishikawa & Rena Noka & Rika Iwata & Asami Iwabuchi & Yushin Watanabe & Natsumi Matsunuma & Kanako Yuki & Hiroki Kobayashi & Yuka Harada & Hirono, 2024. "IL36G-producing neutrophil-like monocytes promote cachexia in cancer," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Rani Pallavi & Elena Gatti & Tiphanie Durfort & Massimo Stendardo & Roberto Ravasio & Tommaso Leonardi & Paolo Falvo & Bruno Achutti Duso & Simona Punzi & Aobuli Xieraili & Andrea Polazzi & Doriana Ve, 2024. "Caloric restriction leads to druggable LSD1-dependent cancer stem cells expansion," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    3. Aidan M. Fenix & Yuichiro Miyaoka & Alessandro Bertero & Steven M. Blue & Matthew J. Spindler & Kenneth K. B. Tan & Juan A. Perez-Bermejo & Amanda H. Chan & Steven J. Mayerl & Trieu D. Nguyen & Caitli, 2021. "Gain-of-function cardiomyopathic mutations in RBM20 rewire splicing regulation and re-distribute ribonucleoprotein granules within processing bodies," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    4. Rowan D Brackston & Eszter Lakatos & Michael P H Stumpf, 2018. "Transition state characteristics during cell differentiation," PLOS Computational Biology, Public Library of Science, vol. 14(9), pages 1-24, September.
    5. Kiara C Eldred & Cameron Avelis & Robert J Johnston Jr & Elijah Roberts, 2020. "Modeling binary and graded cone cell fate patterning in the mouse retina," PLOS Computational Biology, Public Library of Science, vol. 16(3), pages 1-25, March.
    6. Giulia Schiroli & Vinay Kartha & Fabiana M. Duarte & Trine A. Kristiansen & Christina Mayerhofer & Rojesh Shrestha & Andrew Earl & Yan Hu & Tristan Tay & Catherine Rhee & Jason D. Buenrostro & David T, 2024. "Cell of origin epigenetic priming determines susceptibility to Tet2 mutation," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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