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Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system

Author

Listed:
  • Sung Hoon Cho

    (Microbiology and Immunology, Vanderbilt University)

  • Ariel L. Raybuck

    (Microbiology and Immunology, Vanderbilt University)

  • Kristy Stengel

    (Vanderbilt University)

  • Mei Wei

    (Microbiology and Immunology, Vanderbilt University)

  • Thomas C. Beck

    (Microbiology and Immunology, Vanderbilt University)

  • Emmanuel Volanakis

    (Vanderbilt University)

  • James W. Thomas

    (Microbiology and Immunology, Vanderbilt University
    Vanderbilt University)

  • Scott Hiebert

    (Vanderbilt University
    Vanderbilt University
    Vanderbilt-Ingram Cancer Center, Vanderbilt University)

  • Volker H. Haase

    (Vanderbilt University
    Vanderbilt University
    Vanderbilt-Ingram Cancer Center, Vanderbilt University
    Medical and Research Services, Tennessee Valley Healthcare System)

  • Mark R. Boothby

    (Microbiology and Immunology, Vanderbilt University
    Vanderbilt University
    Vanderbilt University
    Vanderbilt-Ingram Cancer Center, Vanderbilt University)

Abstract

Hypoxia in germinal centres regulates B cell class switching via its effects on mTOR complex 1 and activation-induced cytosine deaminase activity.

Suggested Citation

  • Sung Hoon Cho & Ariel L. Raybuck & Kristy Stengel & Mei Wei & Thomas C. Beck & Emmanuel Volanakis & James W. Thomas & Scott Hiebert & Volker H. Haase & Mark R. Boothby, 2016. "Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system," Nature, Nature, vol. 537(7619), pages 234-238, September.
    • Handle: RePEc:nat:nature:v:537:y:2016:i:7619:d:10.1038_nature19334
    DOI: 10.1038/nature19334
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    Citations

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    Cited by:

    1. Wenna Chi & Na Kang & Linlin Sheng & Sichen Liu & Lei Tao & Xizhi Cao & Ye Liu & Can Zhu & Yuming Zhang & Bolong Wu & Ruiqun Chen & Lili Cheng & Jing Wang & Xiaolin Sun & Xiaohui Liu & Haiteng Deng & , 2024. "MCT1-governed pyruvate metabolism is essential for antibody class-switch recombination through H3K27 acetylation," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Bonnie Huang & James D. Phelan & Silvia Preite & Julio Gomez-Rodriguez & Kristoffer H. Johansen & Hirofumi Shibata & Arthur L. Shaffer & Qin Xu & Brendan Jeffrey & Martha Kirby & Stacie Anderson & Yan, 2022. "In vivo CRISPR screens reveal a HIF-1α-mTOR-network regulates T follicular helper versus Th1 cells," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    3. Sophie Hillion & Anjelica Miranda & Christelle Dantec & Marina Boudigou & Laëtitia Pottier & Divi Cornec & Raul M. Torres & Roberta Pelanda, 2024. "Maf expression in B cells restricts reactive plasmablast and germinal center B cell expansion," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    4. Rens Peeters & Jorge Cuenca-Escalona & Esther A. Zaal & Anna T. Hoekstra & Anouk C. G. Balvert & Marcos Vidal-Manrique & Niek Blomberg & Sjoerd J. Deventer & Rinke Stienstra & Julia Jellusova & Martin, 2022. "Fatty acid metabolism in aggressive B-cell lymphoma is inhibited by tetraspanin CD37," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    5. Marta Iborra-Pernichi & Jonathan Ruiz García & María Velasco de la Esperanza & Belén S. Estrada & Elena R. Bovolenta & Claudia Cifuentes & Cristina Prieto Carro & Tamara González Martínez & José Garcí, 2024. "Defective mitochondria remodelling in B cells leads to an aged immune response," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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