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Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala

Author

Listed:
  • Catherine A. Marcinkiewcz

    (Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill)

  • Christopher M. Mazzone

    (Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill
    Curriculum in Neurobiology, School of Medicine, University of North Carolina at Chapel Hill School of Medicine)

  • Giuseppe D’Agostino

    (Rowett Institute of Nutrition and Health, University of Aberdeen)

  • Lindsay R. Halladay

    (National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health)

  • J. Andrew Hardaway

    (Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill)

  • Jeffrey F. DiBerto

    (Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill)

  • Montserrat Navarro

    (College of Arts and Sciences, University of North Carolina at Chapel Hill)

  • Nathan Burnham

    (College of Arts and Sciences, University of North Carolina at Chapel Hill)

  • Claudia Cristiano

    (Rowett Institute of Nutrition and Health, University of Aberdeen)

  • Cayce E. Dorrier

    (Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill)

  • Gregory J. Tipton

    (Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill)

  • Charu Ramakrishnan

    (Stanford University)

  • Tamas Kozicz

    (Hayward Genetics Center, Tulane University
    Radboud University Nijmegen Medical Center)

  • Karl Deisseroth

    (Stanford University)

  • Todd E. Thiele

    (Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill
    College of Arts and Sciences, University of North Carolina at Chapel Hill)

  • Zoe A. McElligott

    (Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill
    School of Medicine, University of North Carolina at Chapel Hill)

  • Andrew Holmes

    (National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health)

  • Lora K. Heisler

    (Rowett Institute of Nutrition and Health, University of Aberdeen)

  • Thomas L. Kash

    (Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill
    Curriculum in Neurobiology, School of Medicine, University of North Carolina at Chapel Hill School of Medicine
    College of Arts and Sciences, University of North Carolina at Chapel Hill
    School of Medicine, University of North Carolina at Chapel Hill)

Abstract

A brain circuit is identified through which serotonin induces an anxiety-like state; this circuit also mediates the anxiety-like behaviour induced by acute administration of the selective serotonin reuptake inhibitor fluoxetine and may underlie the early adverse events that some patients with anxiety disorders have to these types of drugs.

Suggested Citation

  • Catherine A. Marcinkiewcz & Christopher M. Mazzone & Giuseppe D’Agostino & Lindsay R. Halladay & J. Andrew Hardaway & Jeffrey F. DiBerto & Montserrat Navarro & Nathan Burnham & Claudia Cristiano & Cay, 2016. "Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala," Nature, Nature, vol. 537(7618), pages 97-101, September.
    • Handle: RePEc:nat:nature:v:537:y:2016:i:7618:d:10.1038_nature19318
    DOI: 10.1038/nature19318
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    Cited by:

    1. Yang Zhao & Chun-Xiao Huang & Yiming Gu & Yacong Zhao & Wenjie Ren & Yutong Wang & Jinjin Chen & Na N. Guan & Jianren Song, 2024. "Serotonergic modulation of vigilance states in zebrafish and mice," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. M. E. Flanigan & O. J. Hon & S. D’Ambrosio & K. M. Boyt & L. Hassanein & M. Castle & H. L. Haun & M. M. Pina & T. L. Kash, 2023. "Subcortical serotonin 5HT2c receptor-containing neurons sex-specifically regulate binge-like alcohol consumption, social, and arousal behaviors in mice," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    3. Hiro Taiyo Hamada & Yoshifumi Abe & Norio Takata & Masakazu Taira & Kenji F. Tanaka & Kenji Doya, 2024. "Optogenetic activation of dorsal raphe serotonin neurons induces brain-wide activation," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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