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Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region

Author

Listed:
  • A. J. Venkatakrishnan

    (MRC Laboratory of Molecular Biology
    Stanford University School of Medicine
    Stanford University
    Institute for Computational and Mathematical Engineering, Stanford University)

  • Xavier Deupi

    (Paul Scherrer Institute)

  • Guillaume Lebon

    (CNRS UMR 5203, Institut de Génomique Fonctionnelle
    INSERM U1191
    Université Montpellier)

  • Franziska M. Heydenreich

    (Paul Scherrer Institute
    ETH Zurich
    University of Montreal)

  • Tilman Flock

    (MRC Laboratory of Molecular Biology)

  • Tamara Miljus

    (Paul Scherrer Institute
    ETH Zurich)

  • Santhanam Balaji

    (MRC Laboratory of Molecular Biology)

  • Michel Bouvier

    (University of Montreal)

  • Dmitry B. Veprintsev

    (Paul Scherrer Institute
    ETH Zurich)

  • Christopher G. Tate

    (MRC Laboratory of Molecular Biology)

  • Gebhard F. X. Schertler

    (Paul Scherrer Institute
    ETH Zurich)

  • M. Madan Babu

    (MRC Laboratory of Molecular Biology)

Abstract

A highly conserved rearrangement of residue contacts functions as a common step in the activation pathways of diverse G-protein-coupled receptors.

Suggested Citation

  • A. J. Venkatakrishnan & Xavier Deupi & Guillaume Lebon & Franziska M. Heydenreich & Tilman Flock & Tamara Miljus & Santhanam Balaji & Michel Bouvier & Dmitry B. Veprintsev & Christopher G. Tate & Gebh, 2016. "Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region," Nature, Nature, vol. 536(7617), pages 484-487, August.
    • Handle: RePEc:nat:nature:v:536:y:2016:i:7617:d:10.1038_nature19107
    DOI: 10.1038/nature19107
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    Cited by:

    1. Yong-Seok Kim & Jun-Hee Yeon & Woori Ko & Byung-Chang Suh, 2023. "Two-step structural changes in M3 muscarinic receptor activation rely on the coupled Gq protein cycle," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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