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Human commensals producing a novel antibiotic impair pathogen colonization

Author

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  • Alexander Zipperer

    (Interfaculty Institute of Microbiology and Infection Medicine, Infection Biology, University of Tübingen
    German Centre for Infection Research (DZIF), Partner Site Tübingen)

  • Martin C. Konnerth

    (Institute of Organic Chemistry, University of Tübingen)

  • Claudia Laux

    (Interfaculty Institute of Microbiology and Infection Medicine, Infection Biology, University of Tübingen
    German Centre for Infection Research (DZIF), Partner Site Tübingen)

  • Anne Berscheid

    (Interfaculty Institute of Microbiology and Infection Medicine, Microbial Bioactive Compounds, University of Tübingen)

  • Daniela Janek

    (Interfaculty Institute of Microbiology and Infection Medicine, Infection Biology, University of Tübingen
    German Centre for Infection Research (DZIF), Partner Site Tübingen
    †Present address: Boehringer Ingelheim, 88400 Biberach, Germany.)

  • Christopher Weidenmaier

    (German Centre for Infection Research (DZIF), Partner Site Tübingen
    Interfaculty Institute of Microbiology and Infection Medicine, Medical Microbiology, University of Tübingen)

  • Marc Burian

    (University of Tübingen)

  • Nadine A. Schilling

    (Institute of Organic Chemistry, University of Tübingen
    Interfaculty Institute of Biochemistry, University of Tübingen)

  • Christoph Slavetinsky

    (Interfaculty Institute of Microbiology and Infection Medicine, Infection Biology, University of Tübingen
    German Centre for Infection Research (DZIF), Partner Site Tübingen)

  • Matthias Marschal

    (Interfaculty Institute of Microbiology and Infection Medicine, Medical Microbiology, University of Tübingen)

  • Matthias Willmann

    (German Centre for Infection Research (DZIF), Partner Site Tübingen
    Interfaculty Institute of Microbiology and Infection Medicine, Medical Microbiology, University of Tübingen)

  • Hubert Kalbacher

    (Interfaculty Institute of Biochemistry, University of Tübingen)

  • Birgit Schittek

    (University of Tübingen)

  • Heike Brötz-Oesterhelt

    (German Centre for Infection Research (DZIF), Partner Site Tübingen
    Interfaculty Institute of Microbiology and Infection Medicine, Microbial Bioactive Compounds, University of Tübingen)

  • Stephanie Grond

    (Institute of Organic Chemistry, University of Tübingen)

  • Andreas Peschel

    (Interfaculty Institute of Microbiology and Infection Medicine, Infection Biology, University of Tübingen
    German Centre for Infection Research (DZIF), Partner Site Tübingen)

  • Bernhard Krismer

    (Interfaculty Institute of Microbiology and Infection Medicine, Infection Biology, University of Tübingen
    German Centre for Infection Research (DZIF), Partner Site Tübingen)

Abstract

The nasal commensal bacterium Staphylococcus lugdunensis produces a novel cyclic peptide antibiotic, lugdunin, that inhibits colonization by S. aureus in animal models and is associated with a significantly reduced S. aureus carriage rate in humans, suggesting that human commensal bacteria could be a valuable resource for the discovery of new antibiotics.

Suggested Citation

  • Alexander Zipperer & Martin C. Konnerth & Claudia Laux & Anne Berscheid & Daniela Janek & Christopher Weidenmaier & Marc Burian & Nadine A. Schilling & Christoph Slavetinsky & Matthias Marschal & Matt, 2016. "Human commensals producing a novel antibiotic impair pathogen colonization," Nature, Nature, vol. 535(7613), pages 511-516, July.
    • Handle: RePEc:nat:nature:v:535:y:2016:i:7613:d:10.1038_nature18634
    DOI: 10.1038/nature18634
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    Cited by:

    1. Margaret Coleman & Christopher Elkins & Bradford Gutting & Emmanuel Mongodin & Gloria Solano‐Aguilar & Isabel Walls, 2018. "Microbiota and Dose Response: Evolving Paradigm of Health Triangle," Risk Analysis, John Wiley & Sons, vol. 38(10), pages 2013-2028, October.
    2. Dominik Ruppelt & Marius F. W. Trollmann & Taulant Dema & Sebastian N. Wirtz & Hendrik Flegel & Sophia Mönnikes & Stephanie Grond & Rainer A. Böckmann & Claudia Steinem, 2024. "The antimicrobial fibupeptide lugdunin forms water-filled channel structures in lipid membranes," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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