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Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence

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  • Sales Ibiza

    (Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Av. Prof. Egas Moniz, Edifício Egas Moniz)

  • Bethania García-Cassani

    (Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Av. Prof. Egas Moniz, Edifício Egas Moniz)

  • Hélder Ribeiro

    (Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Av. Prof. Egas Moniz, Edifício Egas Moniz)

  • Tânia Carvalho

    (Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Av. Prof. Egas Moniz, Edifício Egas Moniz)

  • Luís Almeida

    (Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Av. Prof. Egas Moniz, Edifício Egas Moniz)

  • Rute Marques

    (Microenvironment and Immunity Unit, Institut Pasteur
    †Present addresses: INSERM, U1163, Laboratory of Intestinal Immunity, and Université Paris Descartes-Sorbonne Paris Cité and Institut Imagine, Paris, France (R.M.); Center for Host-Microbial Interactions, Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pensylvania 19104, USA (A.M.M).)

  • Ana M. Misic

    (Perelman School of Medicine, University of Pennsylvania, 421 Curie Blvd
    †Present addresses: INSERM, U1163, Laboratory of Intestinal Immunity, and Université Paris Descartes-Sorbonne Paris Cité and Institut Imagine, Paris, France (R.M.); Center for Host-Microbial Interactions, Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pensylvania 19104, USA (A.M.M).)

  • Casey Bartow-McKenney

    (Perelman School of Medicine, University of Pennsylvania, 421 Curie Blvd)

  • Denise M. Larson

    (Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health)

  • William J. Pavan

    (Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health)

  • Gérard Eberl

    (Microenvironment and Immunity Unit, Institut Pasteur)

  • Elizabeth A. Grice

    (Perelman School of Medicine, University of Pennsylvania, 421 Curie Blvd)

  • Henrique Veiga-Fernandes

    (Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Av. Prof. Egas Moniz, Edifício Egas Moniz
    Champalimaud Research, Champalimaud Centre for the Unknown)

Abstract

Neurotrophic factors produced by enteric glia in response to microbiota and alarmin cues regulate IL-22 production by group 3 innate lymphoid cells in the gut; disruption of this pathway leads to impaired clearance of Citrobacter rodentium and defects in epithelial integrity in a model of intestinal inflammation.

Suggested Citation

  • Sales Ibiza & Bethania García-Cassani & Hélder Ribeiro & Tânia Carvalho & Luís Almeida & Rute Marques & Ana M. Misic & Casey Bartow-McKenney & Denise M. Larson & William J. Pavan & Gérard Eberl & Eliz, 2016. "Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence," Nature, Nature, vol. 535(7612), pages 440-443, July.
    • Handle: RePEc:nat:nature:v:535:y:2016:i:7612:d:10.1038_nature18644
    DOI: 10.1038/nature18644
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    Cited by:

    1. Hung-Wei Cheng & Urs Mörbe & Mechthild Lütge & Céline Engetschwiler & Lucas Onder & Mario Novkovic & Cristina Gil-Cruz & Christian Perez-Shibayama & Thomas Hehlgans & Elke Scandella & Burkhard Ludewig, 2022. "Intestinal fibroblastic reticular cell niches control innate lymphoid cell homeostasis and function," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    2. Lies van Baarle & Veronica De Simone & Linda Schneider & Sneha Santhosh & Saeed Abdurahiman & Francesca Biscu & Reiner Schneider & Lisa Zanoletti & Renata Siqueira de Mello & Sara Verbandt & Zedong Hu, 2024. "IL-1R signaling drives enteric glia-macrophage interactions in colorectal cancer," Nature Communications, Nature, vol. 15(1), pages 1-22, December.

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