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Host-mediated sugar oxidation promotes post-antibiotic pathogen expansion

Author

Listed:
  • Franziska Faber

    (School of Medicine, University of California at Davis, One Shields Avenue)

  • Lisa Tran

    (School of Medicine, University of California at Davis, One Shields Avenue)

  • Mariana X. Byndloss

    (School of Medicine, University of California at Davis, One Shields Avenue)

  • Christopher A. Lopez

    (School of Medicine, University of California at Davis, One Shields Avenue)

  • Eric M. Velazquez

    (School of Medicine, University of California at Davis, One Shields Avenue)

  • Tobias Kerrinnes

    (School of Medicine, University of California at Davis, One Shields Avenue)

  • Sean-Paul Nuccio

    (School of Medicine, University of California at Davis, One Shields Avenue)

  • Tamding Wangdi

    (School of Medicine, University of California at Davis, One Shields Avenue)

  • Oliver Fiehn

    (Genome Center, University of California at Davis, One Shields Avenue
    King Abdulaziz University)

  • Renée M. Tsolis

    (School of Medicine, University of California at Davis, One Shields Avenue)

  • Andreas J. Bäumler

    (School of Medicine, University of California at Davis, One Shields Avenue)

Abstract

Antibiotic usage in humans can increase the risk of Salmonella infection by an unknown mechanism; this paper reveals that the antibiotic streptomycin increases the activity of the host-encoded enzyme inducible nitric oxide synthase, this then drives Salmonella expansion by the generation of galactarate — a metabolite normally absent from the gut.

Suggested Citation

  • Franziska Faber & Lisa Tran & Mariana X. Byndloss & Christopher A. Lopez & Eric M. Velazquez & Tobias Kerrinnes & Sean-Paul Nuccio & Tamding Wangdi & Oliver Fiehn & Renée M. Tsolis & Andreas J. Bäumle, 2016. "Host-mediated sugar oxidation promotes post-antibiotic pathogen expansion," Nature, Nature, vol. 534(7609), pages 697-699, June.
    • Handle: RePEc:nat:nature:v:534:y:2016:i:7609:d:10.1038_nature18597
    DOI: 10.1038/nature18597
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    Cited by:

    1. Judith Behnsen & Hui Zhi & Allegra T. Aron & Vivekanandan Subramanian & William Santus & Michael H. Lee & Romana R. Gerner & Daniel Petras & Janet Z. Liu & Keith D. Green & Sarah L. Price & Jose Camac, 2021. "Siderophore-mediated zinc acquisition enhances enterobacterial colonization of the inflamed gut," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    2. Courtney Hoskinson & Darlene L. Y. Dai & Kate L. Bel & Allan B. Becker & Theo J. Moraes & Piushkumar J. Mandhane & B. Brett Finlay & Elinor Simons & Anita L. Kozyrskyj & Meghan B. Azad & Padmaja Subba, 2023. "Delayed gut microbiota maturation in the first year of life is a hallmark of pediatric allergic disease," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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