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EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells

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Listed:
  • Jianhua Li

    (University of California, San Francisco
    Howard Hughes Medical Institute, University of California, San Francisco
    Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University)

  • Erick Lu

    (University of California, San Francisco
    Howard Hughes Medical Institute, University of California, San Francisco)

  • Tangsheng Yi

    (University of California, San Francisco
    Howard Hughes Medical Institute, University of California, San Francisco
    † Present address: Department of Discovery Immunology, Genentech, South San Francisco, California 94080, USA.)

  • Jason G. Cyster

    (University of California, San Francisco
    Howard Hughes Medical Institute, University of California, San Francisco)

Abstract

The differentiation of T follicular helper cells requires the G-protein-coupled receptor Ebi2 as well as the interaction with CD25-producing dendritic cells that quench T-cell-derived interleukin-2.

Suggested Citation

  • Jianhua Li & Erick Lu & Tangsheng Yi & Jason G. Cyster, 2016. "EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells," Nature, Nature, vol. 533(7601), pages 110-114, May.
    • Handle: RePEc:nat:nature:v:533:y:2016:i:7601:d:10.1038_nature17947
    DOI: 10.1038/nature17947
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    Cited by:

    1. Meiling Zheng & Zhi Hu & Xiaole Mei & Lianlian Ouyang & Yang Song & Wenhui Zhou & Yi Kong & Ruifang Wu & Shijia Rao & Hai Long & Wei Shi & Hui Jing & Shuang Lu & Haijing Wu & Sujie Jia & Qianjin Lu & , 2022. "Single-cell sequencing shows cellular heterogeneity of cutaneous lesions in lupus erythematosus," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Ivy K Brown & Nathan Dyjack & Mindy M Miller & Harsha Krovi & Cydney Rios & Rachel Woolaver & Laura Harmacek & Ting-Hui Tu & Brian P O’Connor & Thomas Danhorn & Brian Vestal & Laurent Gapin & Clemenci, 2021. "Single cell analysis of host response to helminth infection reveals the clonal breadth, heterogeneity, and tissue-specific programming of the responding CD4+ T cell repertoire," PLOS Pathogens, Public Library of Science, vol. 17(6), pages 1-34, June.

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