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Copper-catalysed enantioselective stereodivergent synthesis of amino alcohols

Author

Listed:
  • Shi-Liang Shi

    (Massachusetts Institute of Technology)

  • Zackary L. Wong

    (Massachusetts Institute of Technology)

  • Stephen L. Buchwald

    (Massachusetts Institute of Technology)

Abstract

Here, a method is described by which to generate all possible stereoisomers of certain amino alcohols—a protocol that should see use in drug discovery and development, where it is important to determine the differing effects of stereoisomeric drug candidates.

Suggested Citation

  • Shi-Liang Shi & Zackary L. Wong & Stephen L. Buchwald, 2016. "Copper-catalysed enantioselective stereodivergent synthesis of amino alcohols," Nature, Nature, vol. 532(7599), pages 353-356, April.
    • Handle: RePEc:nat:nature:v:532:y:2016:i:7599:d:10.1038_nature17191
    DOI: 10.1038/nature17191
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    Cited by:

    1. Biao Chen & Wenhuan Huang & Guoqing Zhang, 2023. "Observation of Chiral-selective room-temperature phosphorescence enhancement via chirality-dependent energy transfer," Nature Communications, Nature, vol. 14(1), pages 1-8, December.
    2. Ran Chen & Ahmad Hammoud & Paméla Aoun & Mayte A. Martínez-Aguirre & Nicolas Vanthuyne & Régina Maruchenko & Patrick Brocorens & Laurent Bouteiller & Matthieu Raynal, 2024. "Switchable supramolecular helices for asymmetric stereodivergent catalysis," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    3. Chang You & Mingying Shi & Xueling Mi & Sanzhong Luo, 2023. "Asymmetric α-allylic allenylation of β-ketocarbonyls and aldehydes by synergistic Pd/chiral primary amine catalysis," Nature Communications, Nature, vol. 14(1), pages 1-7, December.

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