IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v531y2016i7592d10.1038_nature17200.html
   My bibliography  Save this article

Pre-fusion structure of a human coronavirus spike protein

Author

Listed:
  • Robert N. Kirchdoerfer

    (The Scripps Research Institute)

  • Christopher A. Cottrell

    (The Scripps Research Institute)

  • Nianshuang Wang

    (Geisel School of Medicine at Dartmouth)

  • Jesper Pallesen

    (The Scripps Research Institute)

  • Hadi M. Yassine

    (Viral Pathogenesis Laboratory, National Institute of Allergy and Infectious Diseases
    † Present address: Biomedical Research Center, Qatar University, QU-NRC, Zone 5, Room D130, Doha, Qatar.)

  • Hannah L. Turner

    (The Scripps Research Institute)

  • Kizzmekia S. Corbett

    (Viral Pathogenesis Laboratory, National Institute of Allergy and Infectious Diseases)

  • Barney S. Graham

    (Viral Pathogenesis Laboratory, National Institute of Allergy and Infectious Diseases)

  • Jason S. McLellan

    (Geisel School of Medicine at Dartmouth)

  • Andrew B. Ward

    (The Scripps Research Institute)

Abstract

A 4.0 Å resolution cryo-electron microscopy structure of the pre-fusion form of the trimeric spike from the human coronavirus HKU1 provides insight into how the spike protein mediates host-cell attachment and membrane fusion.

Suggested Citation

  • Robert N. Kirchdoerfer & Christopher A. Cottrell & Nianshuang Wang & Jesper Pallesen & Hadi M. Yassine & Hannah L. Turner & Kizzmekia S. Corbett & Barney S. Graham & Jason S. McLellan & Andrew B. Ward, 2016. "Pre-fusion structure of a human coronavirus spike protein," Nature, Nature, vol. 531(7592), pages 118-121, March.
  • Handle: RePEc:nat:nature:v:531:y:2016:i:7592:d:10.1038_nature17200
    DOI: 10.1038/nature17200
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature17200
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1038/nature17200?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Tugba Taskin Tok & Sivakumar J T Gowder, 2020. "An Updated Review on Covid-19 with Special Reference to Structural Elucidation and Functional Properties," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 31(4), pages 24345-24351, November.
    2. Massimo Florio, 2022. "To what extent patents for Covid-19 mRNA vaccines are based on public research and taxpayers’ funding? A case study on the privatization of knowledge [For Billion-Dollar COVID Vaccines, Basic Gover," Industrial and Corporate Change, Oxford University Press and the Associazione ICC, vol. 31(5), pages 1137-1151.
    3. Shahzar Khan & Abdullah & Shah Faisal & Shah Faisal & Hazrat Usman & Rimsha Zainab & Faqeer Taj & Rahma Amrani & Muhammad Tayyeb, 2020. "COVID-19 - A brief overview on the role of Vitamins specifically Vitamin C as immune modulators and in prevention and treatment of SARS-Cov-2 infections," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 28(3), pages 21580-21586, June.
    4. Massimo FLORIO, 2021. "Patents for Covid-19 vaccines are based on public research: a case study on the privatization of knowledge," CIRIEC Working Papers 2103, CIRIEC - Université de Liège.
    5. Timothy J. C. Tan & Zongjun Mou & Ruipeng Lei & Wenhao O. Ouyang & Meng Yuan & Ge Song & Raiees Andrabi & Ian A. Wilson & Collin Kieffer & Xinghong Dai & Kenneth A. Matreyek & Nicholas C. Wu, 2023. "High-throughput identification of prefusion-stabilizing mutations in SARS-CoV-2 spike," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    6. Geoffrey B. Hutchinson & Olubukola M. Abiona & Cynthia T. Ziwawo & Anne P. Werner & Daniel Ellis & Yaroslav Tsybovsky & Sarah R. Leist & Charis Palandjian & Ande West & Ethan J. Fritch & Nianshuang Wa, 2023. "Nanoparticle display of prefusion coronavirus spike elicits S1-focused cross-reactive antibody response against diverse coronavirus subgenera," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:531:y:2016:i:7592:d:10.1038_nature17200. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.