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Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer

Author

Listed:
  • Alexandra C. Walls

    (University of Washington)

  • M. Alejandra Tortorici

    (Institut Pasteur, Unité de Virologie
    CNRS UMR)

  • Berend-Jan Bosch

    (Faculty of Veterinary Medicine, Utrecht University)

  • Brandon Frenz

    (University of Washington)

  • Peter J. M. Rottier

    (Faculty of Veterinary Medicine, Utrecht University)

  • Frank DiMaio

    (University of Washington)

  • Félix A. Rey

    (Institut Pasteur, Unité de Virologie
    CNRS UMR)

  • David Veesler

    (University of Washington)

Abstract

The high-resolution cryo-electron microscopy structure of a pre-fusion coronavirus spike trimer from mouse hepatitis virus is presented; the structure reveals architectural similarities to paramyxovirus F proteins, suggesting that these fusion proteins may have evolved from a distant common ancestor.

Suggested Citation

  • Alexandra C. Walls & M. Alejandra Tortorici & Berend-Jan Bosch & Brandon Frenz & Peter J. M. Rottier & Frank DiMaio & Félix A. Rey & David Veesler, 2016. "Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer," Nature, Nature, vol. 531(7592), pages 114-117, March.
    • Handle: RePEc:nat:nature:v:531:y:2016:i:7592:d:10.1038_nature16988
    DOI: 10.1038/nature16988
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    Cited by:

    1. Tugba Taskin Tok & Sivakumar J T Gowder, 2020. "An Updated Review on Covid-19 with Special Reference to Structural Elucidation and Functional Properties," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 31(4), pages 24345-24351, November.
    2. Wenjuan Du & Oliver Debski-Antoniak & Dubravka Drabek & Rien Haperen & Melissa Dortmondt & Joline Lee & Ieva Drulyte & Frank J. M. Kuppeveld & Frank Grosveld & Daniel L. Hurdiss & Berend-Jan Bosch, 2024. "Neutralizing antibodies reveal cryptic vulnerabilities and interdomain crosstalk in the porcine deltacoronavirus spike protein," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    3. Xintao Song & Lei Bao & Chenjie Feng & Qiang Huang & Fa Zhang & Xin Gao & Renmin Han, 2024. "Accurate Prediction of Protein Structural Flexibility by Deep Learning Integrating Intricate Atomic Structures and Cryo-EM Density Information," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    4. Jimin Lee & Cameron Stewart & Alexandra Schäfer & Elizabeth M. Leaf & Young-Jun Park & Daniel Asarnow & John M. Powers & Catherine Treichel & Kaitlin R. Sprouse & Davide Corti & Ralph Baric & Neil P. , 2024. "A broadly generalizable stabilization strategy for sarbecovirus fusion machinery vaccines," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    5. Antoni G. Wrobel & Donald J. Benton & Chloë Roustan & Annabel Borg & Saira Hussain & Stephen R. Martin & Peter B. Rosenthal & John J. Skehel & Steven J. Gamblin, 2022. "Evolution of the SARS-CoV-2 spike protein in the human host," Nature Communications, Nature, vol. 13(1), pages 1-7, December.

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