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Epithelial tricellular junctions act as interphase cell shape sensors to orient mitosis

Author

Listed:
  • Floris Bosveld

    (Polarity, Institut Curie, CNRS UMR 3215, INSERM U934, 26 rue d’Ulm)

  • Olga Markova

    (Polarity, Institut Curie, CNRS UMR 3215, INSERM U934, 26 rue d’Ulm)

  • Boris Guirao

    (Polarity, Institut Curie, CNRS UMR 3215, INSERM U934, 26 rue d’Ulm)

  • Charlotte Martin

    (Polarity, Institut Curie, CNRS UMR 3215, INSERM U934, 26 rue d’Ulm
    †Present addresses: Institut Curie, CNRS UMR 3348, Université Paris Sud, Bâtiment 110, 91405 Orsay, France (C.M.); INRA, Institut Jean-Pierre Bourgin, UMR 1318, ERL CNRS 3559, Saclay Plant Sciences, RD10, Versailles, France (N.C.); The Francis Crick Institute, Lincoln’s Inn Fields Laboratory, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK (A.A.).)

  • Zhimin Wang

    (Polarity, Institut Curie, CNRS UMR 3215, INSERM U934, 26 rue d’Ulm)

  • Anaëlle Pierre

    (Institut Jacques Monod, CNRS UMR7592 15 rue Hélène Brion)

  • Maria Balakireva

    (Polarity, Institut Curie, CNRS UMR 3215, INSERM U934, 26 rue d’Ulm)

  • Isabelle Gaugue

    (Polarity, Institut Curie, CNRS UMR 3215, INSERM U934, 26 rue d’Ulm)

  • Anna Ainslie

    (Polarity, Institut Curie, CNRS UMR 3215, INSERM U934, 26 rue d’Ulm
    †Present addresses: Institut Curie, CNRS UMR 3348, Université Paris Sud, Bâtiment 110, 91405 Orsay, France (C.M.); INRA, Institut Jean-Pierre Bourgin, UMR 1318, ERL CNRS 3559, Saclay Plant Sciences, RD10, Versailles, France (N.C.); The Francis Crick Institute, Lincoln’s Inn Fields Laboratory, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK (A.A.).)

  • Nicolas Christophorou

    (Polarity, Institut Curie, CNRS UMR 3215, INSERM U934, 26 rue d’Ulm
    †Present addresses: Institut Curie, CNRS UMR 3348, Université Paris Sud, Bâtiment 110, 91405 Orsay, France (C.M.); INRA, Institut Jean-Pierre Bourgin, UMR 1318, ERL CNRS 3559, Saclay Plant Sciences, RD10, Versailles, France (N.C.); The Francis Crick Institute, Lincoln’s Inn Fields Laboratory, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK (A.A.).)

  • David K. Lubensky

    (Polarity, Institut Curie, CNRS UMR 3215, INSERM U934, 26 rue d’Ulm
    University of Michigan)

  • Nicolas Minc

    (Institut Jacques Monod, CNRS UMR7592 15 rue Hélène Brion)

  • Yohanns Bellaïche

    (Polarity, Institut Curie, CNRS UMR 3215, INSERM U934, 26 rue d’Ulm)

Abstract

As fruitfly epithelial cells round up during mitosis, tricellular junctions serve as spatial landmarks, encoding information about interphase cell shape directionality to orient mitosis, and promoting geometric and mechanical sensing in epithelial tissues.

Suggested Citation

  • Floris Bosveld & Olga Markova & Boris Guirao & Charlotte Martin & Zhimin Wang & Anaëlle Pierre & Maria Balakireva & Isabelle Gaugue & Anna Ainslie & Nicolas Christophorou & David K. Lubensky & Nicolas, 2016. "Epithelial tricellular junctions act as interphase cell shape sensors to orient mitosis," Nature, Nature, vol. 530(7591), pages 495-498, February.
    • Handle: RePEc:nat:nature:v:530:y:2016:i:7591:d:10.1038_nature16970
    DOI: 10.1038/nature16970
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    Cited by:

    1. K. Sri-Ranjan & J. L. Sanchez-Alonso & P. Swiatlowska & S. Rothery & P. Novak & S. Gerlach & D. Koeninger & B. Hoffmann & R. Merkel & M. M. Stevens & S. X. Sun & J. Gorelik & Vania M. M. Braga, 2022. "Intrinsic cell rheology drives junction maturation," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    2. Guilherme Ventura & Aboutaleb Amiri & Raghavan Thiagarajan & Mari Tolonen & Amin Doostmohammadi & Jakub Sedzinski, 2022. "Multiciliated cells use filopodia to probe tissue mechanics during epithelial integration in vivo," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Pénélope Darnat & Angélique Burg & Jérémy Sallé & Jérôme Lacoste & Sophie Louvet-Vallée & Michel Gho & Agnès Audibert, 2022. "Cortical Cyclin A controls spindle orientation during asymmetric cell divisions in Drosophila," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    4. Christophe Royer & Elizabeth Sandham & Elizabeth Slee & Falk Schneider & Christoffer B. Lagerholm & Jonathan Godwin & Nisha Veits & Holly Hathrell & Felix Zhou & Karolis Leonavicius & Jemma Garratt & , 2022. "ASPP2 maintains the integrity of mechanically stressed pseudostratified epithelia during morphogenesis," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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