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Cortical Cyclin A controls spindle orientation during asymmetric cell divisions in Drosophila

Author

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  • Pénélope Darnat

    (Sorbonne Université, CNRS, Laboratoire de Biologie du Développement - Institut de Biologie Paris Seine (LBD-IBPS), Cell cycle and cell determination Team)

  • Angélique Burg

    (Sorbonne Université, CNRS, Laboratoire de Biologie du Développement - Institut de Biologie Paris Seine (LBD-IBPS), Cell cycle and cell determination Team)

  • Jérémy Sallé

    (Institut Jacques Monod, Université Paris Diderot/CNRS, Cellular Spatial Organization Team)

  • Jérôme Lacoste

    (Sorbonne Université, CNRS, Laboratoire de Biologie du Développement - Institut de Biologie Paris Seine (LBD-IBPS), Cell cycle and cell determination Team)

  • Sophie Louvet-Vallée

    (Sorbonne Université, CNRS, Laboratoire de Biologie du Développement - Institut de Biologie Paris Seine (LBD-IBPS), Cell cycle and cell determination Team)

  • Michel Gho

    (Sorbonne Université, CNRS, Laboratoire de Biologie du Développement - Institut de Biologie Paris Seine (LBD-IBPS), Cell cycle and cell determination Team)

  • Agnès Audibert

    (Sorbonne Université, CNRS, Laboratoire de Biologie du Développement - Institut de Biologie Paris Seine (LBD-IBPS), Cell cycle and cell determination Team)

Abstract

The coordination between cell proliferation and cell polarity is crucial to orient the asymmetric cell divisions to generate cell diversity in epithelia. In many instances, the Frizzled/Dishevelled planar cell polarity pathway is involved in mitotic spindle orientation, but how this is spatially and temporally coordinated with cell cycle progression has remained elusive. Using Drosophila sensory organ precursor cells as a model system, we show that Cyclin A, the main Cyclin driving the transition to M-phase of the cell cycle, is recruited to the apical-posterior cortex in prophase by the Frizzled/Dishevelled complex. This cortically localized Cyclin A then regulates the orientation of the division by recruiting Mud, a homologue of NuMA, the well-known spindle-associated protein. The observed non-canonical subcellular localization of Cyclin A reveals this mitotic factor as a direct link between cell proliferation, cell polarity and spindle orientation.

Suggested Citation

  • Pénélope Darnat & Angélique Burg & Jérémy Sallé & Jérôme Lacoste & Sophie Louvet-Vallée & Michel Gho & Agnès Audibert, 2022. "Cortical Cyclin A controls spindle orientation during asymmetric cell divisions in Drosophila," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30182-1
    DOI: 10.1038/s41467-022-30182-1
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    References listed on IDEAS

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    1. Michel Gho & François Schweisguth, 1998. "Frizzled signalling controls orientation of asymmetric sense organ precursor cell divisions in Drosophila," Nature, Nature, vol. 393(6681), pages 178-181, May.
    2. Floris Bosveld & Olga Markova & Boris Guirao & Charlotte Martin & Zhimin Wang & Anaëlle Pierre & Maria Balakireva & Isabelle Gaugue & Anna Ainslie & Nicolas Christophorou & David K. Lubensky & Nicolas, 2016. "Epithelial tricellular junctions act as interphase cell shape sensors to orient mitosis," Nature, Nature, vol. 530(7591), pages 495-498, February.
    3. Floris Bosveld & Olga Markova & Boris Guirao & Charlotte Martin & Zhimin Wang & Anaëlle Pierre & Maria Balakireva & Isabelle Gaugue & Anna Ainslie & Nicolas Christophorou & David K. Lubensky & Nicolas, 2016. "Erratum: Epithelial tricellular junctions act as interphase cell shape sensors to orient mitosis," Nature, Nature, vol. 534(7605), pages 138-138, June.
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