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Structure of transcribing mammalian RNA polymerase II

Author

Listed:
  • Carrie Bernecky

    (Max Planck Institute for Biophysical Chemistry)

  • Franz Herzog

    (Gene Center Munich, Ludwig-Maximilians-Universität München)

  • Wolfgang Baumeister

    (Max Planck Institute for Biochemistry)

  • Jürgen M. Plitzko

    (Max Planck Institute for Biochemistry)

  • Patrick Cramer

    (Max Planck Institute for Biophysical Chemistry)

Abstract

The first high-resolution, cryo-electron microscopy structure of mammalian RNA polymerase II, in the form of a transcribing complex comprising DNA template and RNA transcript.

Suggested Citation

  • Carrie Bernecky & Franz Herzog & Wolfgang Baumeister & Jürgen M. Plitzko & Patrick Cramer, 2016. "Structure of transcribing mammalian RNA polymerase II," Nature, Nature, vol. 529(7587), pages 551-554, January.
    • Handle: RePEc:nat:nature:v:529:y:2016:i:7587:d:10.1038_nature16482
    DOI: 10.1038/nature16482
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    Cited by:

    1. Negin Khosraviani & V. Talya Yerlici & Jonathan St-Germain & Yi Yang Hou & Shi Bo Cao & Carla Ghali & Michael Bokros & Rehna Krishnan & Razqallah Hakem & Stephen Lee & Brian Raught & Karim Mekhail, 2024. "Nucleolar Pol II interactome reveals TBPL1, PAF1, and Pol I at intergenic rDNA drive rRNA biogenesis," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Haifeng Hou & Yan Li & Mo Wang & Aijun Liu & Zishuo Yu & Ke Chen & Dan Zhao & Yanhui Xu, 2021. "Structural insights into RNA polymerase III-mediated transcription termination through trapping poly-deoxythymidine," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    3. Johannes Benedum & Vedran Franke & Lisa-Marie Appel & Lena Walch & Melania Bruno & Rebecca Schneeweiss & Juliane Gruber & Helena Oberndorfer & Emma Frank & Xué Strobl & Anton Polyansky & Bojan Zagrovi, 2023. "The SPOC proteins DIDO3 and PHF3 co-regulate gene expression and neuronal differentiation," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    4. Vladyslava Gorbovytska & Seung-Kyoon Kim & Filiz Kuybu & Michael Götze & Dahun Um & Keunsoo Kang & Andreas Pittroff & Theresia Brennecke & Lisa-Marie Schneider & Alexander Leitner & Tae-Kyung Kim & Cl, 2022. "Enhancer RNAs stimulate Pol II pause release by harnessing multivalent interactions to NELF," Nature Communications, Nature, vol. 13(1), pages 1-22, December.
    5. Lisa-Marie Appel & Vedran Franke & Melania Bruno & Irina Grishkovskaya & Aiste Kasiliauskaite & Tanja Kaufmann & Ursula E. Schoeberl & Martin G. Puchinger & Sebastian Kostrhon & Carmen Ebenwaldner & M, 2021. "PHF3 regulates neuronal gene expression through the Pol II CTD reader domain SPOC," Nature Communications, Nature, vol. 12(1), pages 1-24, December.

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