IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v528y2015i7582d10.1038_nature15540.html
   My bibliography  Save this article

Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism

Author

Listed:
  • Derek A. Oldridge

    (Children’s Hospital of Philadelphia
    Medical Scientist Training Program, Perelman School of Medicine at the University of Pennsylvania)

  • Andrew C. Wood

    (University of Auckland)

  • Nina Weichert-Leahey

    (Dana Farber Cancer Institute, Harvard Medical School
    Boston Children’s Hospital)

  • Ian Crimmins

    (Children’s Hospital of Philadelphia)

  • Robyn Sussman

    (Children’s Hospital of Philadelphia)

  • Cynthia Winter

    (Children’s Hospital of Philadelphia)

  • Lee D. McDaniel

    (Children’s Hospital of Philadelphia)

  • Maura Diamond

    (Children’s Hospital of Philadelphia)

  • Lori S. Hart

    (Children’s Hospital of Philadelphia)

  • Shizhen Zhu

    (Mayo Clinic)

  • Adam D. Durbin

    (Dana Farber Cancer Institute, Harvard Medical School
    Boston Children’s Hospital)

  • Brian J. Abraham

    (Whitehead Institute for Biomedical Research and MIT)

  • Lars Anders

    (Whitehead Institute for Biomedical Research and MIT)

  • Lifeng Tian

    (Center for Applied Genomics, Children’s Hospital of Philadelphia)

  • Shile Zhang

    (Pediatric Oncology Branch, National Cancer Institute)

  • Jun S. Wei

    (Pediatric Oncology Branch, National Cancer Institute)

  • Javed Khan

    (Pediatric Oncology Branch, National Cancer Institute)

  • Kelli Bramlett

    (Thermo Fisher Scientific)

  • Nazneen Rahman

    (The Institute of Cancer Research)

  • Mario Capasso

    (University of Naples Federico II
    CEINGE Biotecnologie Avanzate)

  • Achille Iolascon

    (University of Naples Federico II
    CEINGE Biotecnologie Avanzate)

  • Daniela S. Gerhard

    (Office of Cancer Genomics, National Cancer Institute)

  • Jaime M. Guidry Auvil

    (Office of Cancer Genomics, National Cancer Institute)

  • Richard A. Young

    (Whitehead Institute for Biomedical Research and MIT)

  • Hakon Hakonarson

    (Center for Applied Genomics, Children’s Hospital of Philadelphia
    Perelman School of Medicine, University of Pennsylvania)

  • Sharon J. Diskin

    (Children’s Hospital of Philadelphia
    Perelman School of Medicine, University of Pennsylvania
    Abramson Family Cancer Research Institute)

  • A. Thomas Look

    (Dana Farber Cancer Institute, Harvard Medical School
    Boston Children’s Hospital)

  • John M. Maris

    (Children’s Hospital of Philadelphia
    Perelman School of Medicine, University of Pennsylvania
    Abramson Family Cancer Research Institute)

Abstract

A causal variant is identified at the LMO1 oncogene locus that drives the genetic association of LMO1 with neuroblastoma susceptibility; the causal SNP disrupts a GATA transcription factor binding site within a tissue-specific super-enhancer element in the first intron of LMO1, thereby affecting LMO1 expression.

Suggested Citation

  • Derek A. Oldridge & Andrew C. Wood & Nina Weichert-Leahey & Ian Crimmins & Robyn Sussman & Cynthia Winter & Lee D. McDaniel & Maura Diamond & Lori S. Hart & Shizhen Zhu & Adam D. Durbin & Brian J. Abr, 2015. "Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism," Nature, Nature, vol. 528(7582), pages 418-421, December.
    • Handle: RePEc:nat:nature:v:528:y:2015:i:7582:d:10.1038_nature15540
    DOI: 10.1038/nature15540
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature15540
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature15540?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Ting Shen & Ting Ni & Jiaxuan Chen & Haitao Chen & Xiaopin Ma & Guangwen Cao & Tianzhi Wu & Haisheng Xie & Bin Zhou & Gang Wei & Hexige Saiyin & Suqin Shen & Peng Yu & Qianyi Xiao & Hui Liu & Yuzheng , 2022. "An enhancer variant at 16q22.1 predisposes to hepatocellular carcinoma via regulating PRMT7 expression," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Deblina Banerjee & Sukriti Bagchi & Zhihui Liu & Hsien-Chao Chou & Man Xu & Ming Sun & Sara Aloisi & Zalman Vaksman & Sharon J. Diskin & Mark Zimmerman & Javed Khan & Berkley Gryder & Carol J. Thiele, 2024. "Lineage specific transcription factor waves reprogram neuroblastoma from self-renewal to differentiation," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:528:y:2015:i:7582:d:10.1038_nature15540. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.