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A mechanism for expansion of regulatory T-cell repertoire and its role in self-tolerance

Author

Listed:
  • Yongqiang Feng

    (Howard Hughes Medical Institute and Immunology Program, Ludwig Center at Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center)

  • Joris van der Veeken

    (Howard Hughes Medical Institute and Immunology Program, Ludwig Center at Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center)

  • Mikhail Shugay

    (Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS
    Pirogov Russian National Research Medical University, Ostrovityanova 1
    Central European Institute of Technology, Masaryk University)

  • Ekaterina V. Putintseva

    (Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS
    Central European Institute of Technology, Masaryk University)

  • Hatice U. Osmanbeyoglu

    (Computational Biology Program, Memorial Sloan Kettering Cancer Center)

  • Stanislav Dikiy

    (Howard Hughes Medical Institute and Immunology Program, Ludwig Center at Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center)

  • Beatrice E. Hoyos

    (Howard Hughes Medical Institute and Immunology Program, Ludwig Center at Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center)

  • Bruno Moltedo

    (Howard Hughes Medical Institute and Immunology Program, Ludwig Center at Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center)

  • Saskia Hemmers

    (Howard Hughes Medical Institute and Immunology Program, Ludwig Center at Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center)

  • Piper Treuting

    (School of Medicine, University of Washington)

  • Christina S. Leslie

    (Computational Biology Program, Memorial Sloan Kettering Cancer Center)

  • Dmitriy M. Chudakov

    (Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS
    Pirogov Russian National Research Medical University, Ostrovityanova 1
    Central European Institute of Technology, Masaryk University)

  • Alexander Y. Rudensky

    (Howard Hughes Medical Institute and Immunology Program, Ludwig Center at Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center)

Abstract

Regulatory T cells need to express a diverse T-cell-receptor repertoire to control pathogenic self-reactive T cells; here it is shown that repertoire diversification depends on the intronic Foxp3 enhancer CNS3 acting at the regulatory T-cell-precursor stage to induce T-cell-receptor responsiveness to low-strength signals.

Suggested Citation

  • Yongqiang Feng & Joris van der Veeken & Mikhail Shugay & Ekaterina V. Putintseva & Hatice U. Osmanbeyoglu & Stanislav Dikiy & Beatrice E. Hoyos & Bruno Moltedo & Saskia Hemmers & Piper Treuting & Chri, 2015. "A mechanism for expansion of regulatory T-cell repertoire and its role in self-tolerance," Nature, Nature, vol. 528(7580), pages 132-136, December.
    • Handle: RePEc:nat:nature:v:528:y:2015:i:7580:d:10.1038_nature16141
    DOI: 10.1038/nature16141
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    Cited by:

    1. Mikhail Shugay & Dmitriy V Bagaev & Maria A Turchaninova & Dmitriy A Bolotin & Olga V Britanova & Ekaterina V Putintseva & Mikhail V Pogorelyy & Vadim I Nazarov & Ivan V Zvyagin & Vitalina I Kirgizova, 2015. "VDJtools: Unifying Post-analysis of T Cell Receptor Repertoires," PLOS Computational Biology, Public Library of Science, vol. 11(11), pages 1-16, November.

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