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Autophagy mediates degradation of nuclear lamina

Author

Listed:
  • Zhixun Dou

    (Epigenetics Program, Perelman School of Medicine, University of Pennsylvania)

  • Caiyue Xu

    (Epigenetics Program, Perelman School of Medicine, University of Pennsylvania)

  • Greg Donahue

    (Epigenetics Program, Perelman School of Medicine, University of Pennsylvania)

  • Takeshi Shimi

    (Feinberg School of Medicine, Northwestern University)

  • Ji-An Pan

    (Stony Brook University)

  • Jiajun Zhu

    (Epigenetics Program, Perelman School of Medicine, University of Pennsylvania)

  • Andrejs Ivanov

    (Institute of Cancer Sciences, University of Glasgow and Beatson Institute for Cancer Research
    † Present address: Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.)

  • Brian C. Capell

    (Epigenetics Program, Perelman School of Medicine, University of Pennsylvania)

  • Adam M. Drake

    (Epigenetics Program, Perelman School of Medicine, University of Pennsylvania)

  • Parisha P. Shah

    (Epigenetics Program, Perelman School of Medicine, University of Pennsylvania)

  • Joseph M. Catanzaro

    (Stony Brook University)

  • M. Daniel Ricketts

    (University of Pennsylvania)

  • Trond Lamark

    (Molecular Cancer Research Group, Institute of Medical Biology, University of Tromsø – The Arctic University of Norway)

  • Stephen A. Adam

    (Feinberg School of Medicine, Northwestern University)

  • Ronen Marmorstein

    (University of Pennsylvania
    University of Pennsylvania
    Abramson Family Cancer Research Institute, University of Pennsylvania)

  • Wei-Xing Zong

    (Stony Brook University)

  • Terje Johansen

    (Molecular Cancer Research Group, Institute of Medical Biology, University of Tromsø – The Arctic University of Norway)

  • Robert D. Goldman

    (Feinberg School of Medicine, Northwestern University)

  • Peter D. Adams

    (Institute of Cancer Sciences, University of Glasgow and Beatson Institute for Cancer Research)

  • Shelley L. Berger

    (Epigenetics Program, Perelman School of Medicine, University of Pennsylvania)

Abstract

In response to cancer-associated stress, autophagy machinery mediates degradation of nuclear lamina components in mammals, suggesting that cells might degrade nuclear components to prevent tumorigenesis.

Suggested Citation

  • Zhixun Dou & Caiyue Xu & Greg Donahue & Takeshi Shimi & Ji-An Pan & Jiajun Zhu & Andrejs Ivanov & Brian C. Capell & Adam M. Drake & Parisha P. Shah & Joseph M. Catanzaro & M. Daniel Ricketts & Trond L, 2015. "Autophagy mediates degradation of nuclear lamina," Nature, Nature, vol. 527(7576), pages 105-109, November.
    • Handle: RePEc:nat:nature:v:527:y:2015:i:7576:d:10.1038_nature15548
    DOI: 10.1038/nature15548
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    Cited by:

    1. Humza M. Ashraf & Brianna Fernandez & Sabrina L. Spencer, 2023. "The intensities of canonical senescence biomarkers integrate the duration of cell-cycle withdrawal," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Juan Li & Yang Wang & Yue Luo & Yang Liu & Yong Yi & Jinsong Li & Yang Pan & Weiyuxin Li & Wanbang You & Qingyong Hu & Zhiqiang Zhao & Yujun Zhang & Yang Cao & Lingqiang Zhang & Junying Yuan & Zhi-Xio, 2022. "USP5-Beclin 1 axis overrides p53-dependent senescence and drives Kras-induced tumorigenicity," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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