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Pharmacogenomics in the clinic

Author

Listed:
  • Mary V. Relling

    (St. Jude Children's Research Hospital)

  • William E. Evans

    (St. Jude Children's Research Hospital)

Abstract

After decades of discovery, inherited variations have been identified in approximately 20 genes that affect about 80 medications and are actionable in the clinic. And some somatically acquired genetic variants direct the choice of 'targeted' anticancer drugs for individual patients. Current efforts that focus on the processes required to appropriately act on pharmacogenomic variability in the clinic are moving away from discovery and towards implementation of an evidenced-based strategy for improving the use of medications, thereby providing a cornerstone for precision medicine.

Suggested Citation

  • Mary V. Relling & William E. Evans, 2015. "Pharmacogenomics in the clinic," Nature, Nature, vol. 526(7573), pages 343-350, October.
    • Handle: RePEc:nat:nature:v:526:y:2015:i:7573:d:10.1038_nature15817
    DOI: 10.1038/nature15817
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    Cited by:

    1. Degtiar, Irina, 2017. "A review of international coverage and pricing strategies for personalized medicine and orphan drugs," Health Policy, Elsevier, vol. 121(12), pages 1240-1248.
    2. Ya-Yen Yu & Shih-Ming Tsao & Wen-Ta Yang & Wei-Chang Huang & Ching-Hsiung Lin & Wei-Wen Chen & Shun-Fa Yang & Hui-Ling Chiou & Yi-Wen Huang, 2019. "Association of Drug Metabolic Enzyme Genetic Polymorphisms and Adverse Drug Reactions in Patients Receiving Rifapentine and Isoniazid Therapy for Latent Tuberculosis," IJERPH, MDPI, vol. 17(1), pages 1-9, December.
    3. M Dahmani Fathallah, 2017. "Genomics, Gene Editing and Biologics: The Bolsters of the New Medical Paradigm," Current Trends in Biomedical Engineering & Biosciences, Juniper Publishers Inc., vol. 6(4), pages 75-78, July.
    4. Ligia Traldi Macedo & Vinicius Eduardo Ferrari & Juliana Carron & Ericka Francislaine Dias Costa & Leisa Lopes-Aguiar & Gustavo Jacob Lourenço & Carmen Silvia Passos Lima, 2019. "Cost-minimization analysis of GSTP1c.313A>G genotyping for the prevention of cisplatin-induced nausea and vomiting: A Bayesian inference approach," PLOS ONE, Public Library of Science, vol. 14(3), pages 1-13, March.
    5. Perry, Seth W & Allison, Stephen & Bastiampillai, Tarun & Wong, Ma-Li & Licinio, Julio & Sharfstein, Steven S. & Wilcox, Holly C., 2019. "Rising US Suicides: Achieving Health Equity," OSF Preprints m5q64, Center for Open Science.
    6. Jiao Zhai & Yingying Liu & Weiqing Ji & Xinru Huang & Ping Wang & Yunyi Li & Haoran Li & Ada Hang-Heng Wong & Xiong Zhou & Ping Chen & Lianhong Wang & Ning Yang & Chi Chen & Haitian Chen & Pui-In Mak , 2024. "Drug screening on digital microfluidics for cancer precision medicine," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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