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The genomic landscape of response to EGFR blockade in colorectal cancer

Author

Listed:
  • Andrea Bertotti

    (University of Turin Medical School
    Translational Cancer Medicine, Surgical Oncology, and Clinical Trials Coordination, Candiolo Cancer Institute – Fondazione del Piemonte per l’Oncologia IRCCS
    National Institute of Biostructures and Biosystems (INBB))

  • Eniko Papp

    (Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine)

  • Siân Jones

    (Personal Genome Diagnostics)

  • Vilmos Adleff

    (Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine)

  • Valsamo Anagnostou

    (Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine)

  • Barbara Lupo

    (University of Turin Medical School
    Translational Cancer Medicine, Surgical Oncology, and Clinical Trials Coordination, Candiolo Cancer Institute – Fondazione del Piemonte per l’Oncologia IRCCS)

  • Mark Sausen

    (Personal Genome Diagnostics)

  • Jillian Phallen

    (Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine)

  • Carolyn A. Hruban

    (Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine)

  • Collin Tokheim

    (Institute for Computational Medicine, Johns Hopkins University)

  • Noushin Niknafs

    (Institute for Computational Medicine, Johns Hopkins University)

  • Monica Nesselbush

    (Personal Genome Diagnostics)

  • Karli Lytle

    (Personal Genome Diagnostics)

  • Francesco Sassi

    (Translational Cancer Medicine, Surgical Oncology, and Clinical Trials Coordination, Candiolo Cancer Institute – Fondazione del Piemonte per l’Oncologia IRCCS)

  • Francesca Cottino

    (Translational Cancer Medicine, Surgical Oncology, and Clinical Trials Coordination, Candiolo Cancer Institute – Fondazione del Piemonte per l’Oncologia IRCCS)

  • Giorgia Migliardi

    (University of Turin Medical School
    Translational Cancer Medicine, Surgical Oncology, and Clinical Trials Coordination, Candiolo Cancer Institute – Fondazione del Piemonte per l’Oncologia IRCCS)

  • Eugenia R. Zanella

    (University of Turin Medical School
    Translational Cancer Medicine, Surgical Oncology, and Clinical Trials Coordination, Candiolo Cancer Institute – Fondazione del Piemonte per l’Oncologia IRCCS)

  • Dario Ribero

    (Mauriziano Umberto I Hospital
    †Present address: European Institute of Oncology (IEO), 20141 Milan, Italy)

  • Nadia Russolillo

    (Mauriziano Umberto I Hospital)

  • Alfredo Mellano

    (Translational Cancer Medicine, Surgical Oncology, and Clinical Trials Coordination, Candiolo Cancer Institute – Fondazione del Piemonte per l’Oncologia IRCCS)

  • Andrea Muratore

    (Translational Cancer Medicine, Surgical Oncology, and Clinical Trials Coordination, Candiolo Cancer Institute – Fondazione del Piemonte per l’Oncologia IRCCS)

  • Gianluca Paraluppi

    (Liver Transplantation Center, San Giovanni Battista Hospital)

  • Mauro Salizzoni

    (Liver Transplantation Center, San Giovanni Battista Hospital
    University of Turin Medical School)

  • Silvia Marsoni

    (Translational Cancer Medicine, Surgical Oncology, and Clinical Trials Coordination, Candiolo Cancer Institute – Fondazione del Piemonte per l’Oncologia IRCCS)

  • Michael Kragh

    (Symphogen A/S)

  • Johan Lantto

    (Symphogen A/S)

  • Andrea Cassingena

    (Niguarda Cancer Center, Ospedale Niguarda Ca’ Granda)

  • Qing Kay Li

    (Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine)

  • Rachel Karchin

    (Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
    Institute for Computational Medicine, Johns Hopkins University)

  • Robert Scharpf

    (Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine)

  • Andrea Sartore-Bianchi

    (Niguarda Cancer Center, Ospedale Niguarda Ca’ Granda)

  • Salvatore Siena

    (Niguarda Cancer Center, Ospedale Niguarda Ca’ Granda
    University of Milan Medical School)

  • Luis A. Diaz

    (Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
    Swim Across America Laboratory, The Ludwig Center for Cancer Genetics and Therapeutics at Johns Hopkins)

  • Livio Trusolino

    (University of Turin Medical School
    Translational Cancer Medicine, Surgical Oncology, and Clinical Trials Coordination, Candiolo Cancer Institute – Fondazione del Piemonte per l’Oncologia IRCCS)

  • Victor E. Velculescu

    (Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine)

Abstract

The effect of somatic genetic changes in colorectal cancer on sensitivity to anti-EGFR antibody therapy is analysed.

Suggested Citation

  • Andrea Bertotti & Eniko Papp & Siân Jones & Vilmos Adleff & Valsamo Anagnostou & Barbara Lupo & Mark Sausen & Jillian Phallen & Carolyn A. Hruban & Collin Tokheim & Noushin Niknafs & Monica Nesselbush, 2015. "The genomic landscape of response to EGFR blockade in colorectal cancer," Nature, Nature, vol. 526(7572), pages 263-267, October.
    • Handle: RePEc:nat:nature:v:526:y:2015:i:7572:d:10.1038_nature14969
    DOI: 10.1038/nature14969
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    Citations

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    Cited by:

    1. Yan Li & Bing Wang & Wentao Yang & Fahan Ma & Jianling Zou & Kai Li & Subei Tan & Jinwen Feng & Yunzhi Wang & Zhaoyu Qin & Zhiyu Chen & Chen Ding, 2024. "Longitudinal plasma proteome profiling reveals the diversity of biomarkers for diagnosis and cetuximab therapy response of colorectal cancer," Nature Communications, Nature, vol. 15(1), pages 1-23, December.
    2. Umberto Perron & Elena Grassi & Aikaterini Chatzipli & Marco Viviani & Emre Karakoc & Lucia Trastulla & Lorenzo M. Brochier & Claudio Isella & Eugenia R. Zanella & Hagen Klett & Ivan Molineris & Julia, 2024. "Integrative ensemble modelling of cetuximab sensitivity in colorectal cancer patient-derived xenografts," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    3. Simonetta M. Leto & Elena Grassi & Marco Avolio & Valentina Vurchio & Francesca Cottino & Martina Ferri & Eugenia R. Zanella & Sofia Borgato & Giorgio Corti & Laura Blasio & Desiana Somale & Marianela, 2024. "XENTURION is a population-level multidimensional resource of xenografts and tumoroids from metastatic colorectal cancer patients," Nature Communications, Nature, vol. 15(1), pages 1-22, December.
    4. Radia M. Johnson & Xueping Qu & Chu-Fang Lin & Ling-Yuh Huw & Avinashnarayan Venkatanarayan & Ethan Sokol & Fang-Shu Ou & Nnamdi Ihuegbu & Oliver A. Zill & Omar Kabbarah & Lisa Wang & Richard Bourgon , 2022. "ARID1A mutations confer intrinsic and acquired resistance to cetuximab treatment in colorectal cancer," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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