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In situ structural analysis of the human nuclear pore complex

Author

Listed:
  • Alexander von Appen

    (European Molecular Biology Laboratory, Structural and Computational Biology Unit)

  • Jan Kosinski

    (European Molecular Biology Laboratory, Structural and Computational Biology Unit)

  • Lenore Sparks

    (European Molecular Biology Laboratory, Structural and Computational Biology Unit)

  • Alessandro Ori

    (European Molecular Biology Laboratory, Structural and Computational Biology Unit)

  • Amanda L. DiGuilio

    (Chemical Biology and Biomedical Engineering, Stevens Institute of Technology)

  • Benjamin Vollmer

    (Friedrich Miescher Laboratory of the Max Planck Society
    †Present address: Oxford Particle Imaging Centre, Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK)

  • Marie-Therese Mackmull

    (European Molecular Biology Laboratory, Structural and Computational Biology Unit)

  • Niccolo Banterle

    (European Molecular Biology Laboratory, Structural and Computational Biology Unit)

  • Luca Parca

    (European Molecular Biology Laboratory, Structural and Computational Biology Unit)

  • Panagiotis Kastritis

    (European Molecular Biology Laboratory, Structural and Computational Biology Unit)

  • Katarzyna Buczak

    (European Molecular Biology Laboratory, Structural and Computational Biology Unit)

  • Shyamal Mosalaganti

    (European Molecular Biology Laboratory, Structural and Computational Biology Unit)

  • Wim Hagen

    (European Molecular Biology Laboratory, Structural and Computational Biology Unit)

  • Amparo Andres-Pons

    (European Molecular Biology Laboratory, Structural and Computational Biology Unit)

  • Edward A. Lemke

    (European Molecular Biology Laboratory, Structural and Computational Biology Unit)

  • Peer Bork

    (European Molecular Biology Laboratory, Structural and Computational Biology Unit)

  • Wolfram Antonin

    (Friedrich Miescher Laboratory of the Max Planck Society)

  • Joseph S. Glavy

    (Chemical Biology and Biomedical Engineering, Stevens Institute of Technology)

  • Khanh Huy Bui

    (European Molecular Biology Laboratory, Structural and Computational Biology Unit
    McGill University)

  • Martin Beck

    (European Molecular Biology Laboratory, Structural and Computational Biology Unit)

Abstract

The most comprehensive architectural model to date of the nuclear pore complex reveals previously unknown local interactions, and a role for nucleoporin 358 in Y-complex oligomerization.

Suggested Citation

  • Alexander von Appen & Jan Kosinski & Lenore Sparks & Alessandro Ori & Amanda L. DiGuilio & Benjamin Vollmer & Marie-Therese Mackmull & Niccolo Banterle & Luca Parca & Panagiotis Kastritis & Katarzyna , 2015. "In situ structural analysis of the human nuclear pore complex," Nature, Nature, vol. 526(7571), pages 140-143, October.
    • Handle: RePEc:nat:nature:v:526:y:2015:i:7571:d:10.1038_nature15381
    DOI: 10.1038/nature15381
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    Citations

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    Cited by:

    1. Vincent Louvel & Romuald Haase & Olivier Mercey & Marine H. Laporte & Thibaut Eloy & Étienne Baudrier & Denis Fortun & Dominique Soldati-Favre & Virginie Hamel & Paul Guichard, 2023. "iU-ExM: nanoscopy of organelles and tissues with iterative ultrastructure expansion microscopy," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Mark F. Santos & Germana Rappa & Jana Karbanová & Patrizia Diana & Girolamo Cirrincione & Daniela Carbone & David Manna & Feryal Aalam & David Wang & Cheryl Vanier & Denis Corbeil & Aurelio Lorico, 2023. "HIV-1-induced nuclear invaginations mediated by VAP-A, ORP3, and Rab7 complex explain infection of activated T cells," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    3. Michael P Lake & Louis-S Bouchard, 2017. "Targeted nanodiamonds for identification of subcellular protein assemblies in mammalian cells," PLOS ONE, Public Library of Science, vol. 12(6), pages 1-18, June.
    4. David Winogradoff & Han-Yi Chou & Christopher Maffeo & Aleksei Aksimentiev, 2022. "Percolation transition prescribes protein size-specific barrier to passive transport through the nuclear pore complex," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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