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Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells

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  • Devon A. Lawson

    (University of California
    †Present addresses: Department of Physiology and Biophysics, University of California, Irvine, California 92697, USA (D.A.L.); Department of Biological Chemistry, University of California, Irvine, California 92697, USA (K.K.); Institute of Molecular Life Sciences, University of Zürich, Zürich 8057, Switzerland (K.D.P.); Saitama Cancer Center, Saitama 362-0806, Japan (K.T.).)

  • Nirav R. Bhakta

    (University of California)

  • Kai Kessenbrock

    (University of California
    University of California
    †Present addresses: Department of Physiology and Biophysics, University of California, Irvine, California 92697, USA (D.A.L.); Department of Biological Chemistry, University of California, Irvine, California 92697, USA (K.K.); Institute of Molecular Life Sciences, University of Zürich, Zürich 8057, Switzerland (K.D.P.); Saitama Cancer Center, Saitama 362-0806, Japan (K.T.).)

  • Karin D. Prummel

    (University of California
    †Present addresses: Department of Physiology and Biophysics, University of California, Irvine, California 92697, USA (D.A.L.); Department of Biological Chemistry, University of California, Irvine, California 92697, USA (K.K.); Institute of Molecular Life Sciences, University of Zürich, Zürich 8057, Switzerland (K.D.P.); Saitama Cancer Center, Saitama 362-0806, Japan (K.T.).)

  • Ying Yu

    (University of California)

  • Ken Takai

    (University of California
    †Present addresses: Department of Physiology and Biophysics, University of California, Irvine, California 92697, USA (D.A.L.); Department of Biological Chemistry, University of California, Irvine, California 92697, USA (K.K.); Institute of Molecular Life Sciences, University of Zürich, Zürich 8057, Switzerland (K.D.P.); Saitama Cancer Center, Saitama 362-0806, Japan (K.T.).)

  • Alicia Zhou

    (University of California)

  • Henok Eyob

    (University of California)

  • Sanjeev Balakrishnan

    (University of California)

  • Chih-Yang Wang

    (University of California
    Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University)

  • Paul Yaswen

    (Lawrence Berkeley National Laboratory)

  • Andrei Goga

    (University of California
    University of California)

  • Zena Werb

    (University of California)

Abstract

Single-cell analysis of gene expression in metastatic cells from distinct human breast tumour models shows that early metastatic cells possess basal, stem and mesenchymal cell properties, whereas advanced metastatic cells have more proliferative properties and are more mature, enabling them to be targeted with an anti-proliferative compound.

Suggested Citation

  • Devon A. Lawson & Nirav R. Bhakta & Kai Kessenbrock & Karin D. Prummel & Ying Yu & Ken Takai & Alicia Zhou & Henok Eyob & Sanjeev Balakrishnan & Chih-Yang Wang & Paul Yaswen & Andrei Goga & Zena Werb, 2015. "Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells," Nature, Nature, vol. 526(7571), pages 131-135, October.
    • Handle: RePEc:nat:nature:v:526:y:2015:i:7571:d:10.1038_nature15260
    DOI: 10.1038/nature15260
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    Cited by:

    1. Mingming Wu & Xiao Zhang & Weijie Zhang & Yi Shiou Chiou & Wenchang Qian & Xiangtian Liu & Min Zhang & Hong Yan & Shilan Li & Tao Li & Xinghua Han & Pengxu Qian & Suling Liu & Yueyin Pan & Peter E. Lo, 2022. "Cancer stem cell regulated phenotypic plasticity protects metastasized cancer cells from ferroptosis," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Yael Aylon & Noa Furth & Giuseppe Mallel & Gilgi Friedlander & Nishanth Belugali Nataraj & Meng Dong & Ori Hassin & Rawan Zoabi & Benjamin Cohen & Vanessa Drendel & Tomer Meir Salame & Saptaparna Mukh, 2022. "Breast cancer plasticity is restricted by a LATS1-NCOR1 repressive axis," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    3. Gat Rauner & Dexter X. Jin & Daniel H. Miller & Todd M. Gierahn & Carman M. Li & Ethan S. Sokol & Yu-Xiong Feng & Robert A. Mathis & J. Christopher Love & Piyush B. Gupta & Charlotte Kuperwasser, 2021. "Breast tissue regeneration is driven by cell-matrix interactions coordinating multi-lineage stem cell differentiation through DDR1," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    4. Joyce V. Lee & Filomena Housley & Christina Yau & Rachel Nakagawa & Juliane Winkler & Johanna M. Anttila & Pauliina M. Munne & Mariel Savelius & Kathleen E. Houlahan & Daniel Mark & Golzar Hemmati & G, 2022. "Combinatorial immunotherapies overcome MYC-driven immune evasion in triple negative breast cancer," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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