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Integrator mediates the biogenesis of enhancer RNAs

Author

Listed:
  • Fan Lai

    (University of Miami Miller School of Medicine, Sylvester Comprehensive Cancer Center, Biomedical Research Building)

  • Alessandro Gardini

    (University of Miami Miller School of Medicine, Sylvester Comprehensive Cancer Center, Biomedical Research Building)

  • Anda Zhang

    (University of Miami Miller School of Medicine, Sylvester Comprehensive Cancer Center, Biomedical Research Building)

  • Ramin Shiekhattar

    (University of Miami Miller School of Medicine, Sylvester Comprehensive Cancer Center, Biomedical Research Building)

Abstract

This study demonstrates a role for the Integrator complex in the stimulus-dependent induction of eRNAs and their 3′ processing; together with previously known roles of Integrator in transcription elongation and RNA processing, these results indicate that Integrator has broad functions in the regulation of eukaryotic gene expression.

Suggested Citation

  • Fan Lai & Alessandro Gardini & Anda Zhang & Ramin Shiekhattar, 2015. "Integrator mediates the biogenesis of enhancer RNAs," Nature, Nature, vol. 525(7569), pages 399-403, September.
    • Handle: RePEc:nat:nature:v:525:y:2015:i:7569:d:10.1038_nature14906
    DOI: 10.1038/nature14906
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    Cited by:

    1. Buki Kwon & Mervin M. Fansler & Neil D. Patel & Jihye Lee & Weirui Ma & Christine Mayr, 2022. "Enhancers regulate 3′ end processing activity to control expression of alternative 3′UTR isoforms," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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