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PIK3CAH1047R induces multipotency and multi-lineage mammary tumours

Author

Listed:
  • Shany Koren

    (Friedrich Miescher Institute for Biomedical Research (FMI))

  • Linsey Reavie

    (Friedrich Miescher Institute for Biomedical Research (FMI))

  • Joana Pinto Couto

    (Friedrich Miescher Institute for Biomedical Research (FMI))

  • Duvini De Silva

    (Friedrich Miescher Institute for Biomedical Research (FMI))

  • Michael B. Stadler

    (Friedrich Miescher Institute for Biomedical Research (FMI)
    Swiss Institute of Bioinformatics)

  • Tim Roloff

    (Friedrich Miescher Institute for Biomedical Research (FMI))

  • Adrian Britschgi

    (Friedrich Miescher Institute for Biomedical Research (FMI))

  • Tobias Eichlisberger

    (Friedrich Miescher Institute for Biomedical Research (FMI))

  • Hubertus Kohler

    (Friedrich Miescher Institute for Biomedical Research (FMI))

  • Olulanu Aina

    (Center for Comparative Medicine, University of California Davis)

  • Robert D. Cardiff

    (Center for Comparative Medicine, University of California Davis)

  • Mohamed Bentires-Alj

    (Friedrich Miescher Institute for Biomedical Research (FMI))

Abstract

PIK3CA mutations are associated with distinct types of human breast cancers but the cellular origin and mechanisms responsible for this heterogeneity were unclear; here, using a genetic approach in mice, the PIK3CAH1047R mutation is shown to induce multipotent stem-like cells and mammary tumours with different levels of malignancy depending on the cell of origin.

Suggested Citation

  • Shany Koren & Linsey Reavie & Joana Pinto Couto & Duvini De Silva & Michael B. Stadler & Tim Roloff & Adrian Britschgi & Tobias Eichlisberger & Hubertus Kohler & Olulanu Aina & Robert D. Cardiff & Moh, 2015. "PIK3CAH1047R induces multipotency and multi-lineage mammary tumours," Nature, Nature, vol. 525(7567), pages 114-118, September.
    • Handle: RePEc:nat:nature:v:525:y:2015:i:7567:d:10.1038_nature14669
    DOI: 10.1038/nature14669
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    Cited by:

    1. Yael Aylon & Noa Furth & Giuseppe Mallel & Gilgi Friedlander & Nishanth Belugali Nataraj & Meng Dong & Ori Hassin & Rawan Zoabi & Benjamin Cohen & Vanessa Drendel & Tomer Meir Salame & Saptaparna Mukh, 2022. "Breast cancer plasticity is restricted by a LATS1-NCOR1 repressive axis," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    2. Joseph G. Kern & Andrew M. Tilston-Lunel & Anthony Federico & Boting Ning & Amy Mueller & Grace B. Peppler & Eleni Stampouloglou & Nan Cheng & Randy L. Johnson & Marc E. Lenburg & Jennifer E. Beane & , 2022. "Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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