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Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity

Author

Listed:
  • Alexandra Van Keymeulen

    (Université Libre de Bruxelles)

  • May Yin Lee

    (Université Libre de Bruxelles)

  • Marielle Ousset

    (Université Libre de Bruxelles)

  • Sylvain Brohée

    (Institut Jules Bordet, Université Libre de Bruxelles)

  • Sandrine Rorive

    (Erasme Hospital, Université Libre de Bruxelles
    DIAPATH — Center for Microscopy and Molecular Imaging (CMMI))

  • Rajshekhar R. Giraddi

    (Université Libre de Bruxelles)

  • Aline Wuidart

    (Université Libre de Bruxelles)

  • Gaëlle Bouvencourt

    (Université Libre de Bruxelles)

  • Christine Dubois

    (Université Libre de Bruxelles)

  • Isabelle Salmon

    (Erasme Hospital, Université Libre de Bruxelles
    DIAPATH — Center for Microscopy and Molecular Imaging (CMMI))

  • Christos Sotiriou

    (Institut Jules Bordet, Université Libre de Bruxelles)

  • Wayne A. Phillips

    (Surgical Oncology Research Laboratory, Peter MacCallum Cancer Centre
    University of Melbourne)

  • Cédric Blanpain

    (Université Libre de Bruxelles
    WELBIO, Université Libre de Bruxelles)

Abstract

PIK3CA mutations are associated with distinct types of human breast cancers but the cellular origin and mechanisms responsible for this heterogeneity were unclear; here, using a genetic approach in mice, PIK3CA mutations are shown to activate a genetic program directing multiple cell fates in normally lineage-restricted cell types.

Suggested Citation

  • Alexandra Van Keymeulen & May Yin Lee & Marielle Ousset & Sylvain Brohée & Sandrine Rorive & Rajshekhar R. Giraddi & Aline Wuidart & Gaëlle Bouvencourt & Christine Dubois & Isabelle Salmon & Christos , 2015. "Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity," Nature, Nature, vol. 525(7567), pages 119-123, September.
    • Handle: RePEc:nat:nature:v:525:y:2015:i:7567:d:10.1038_nature14665
    DOI: 10.1038/nature14665
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