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SEC14L2 enables pan-genotype HCV replication in cell culture

Author

Listed:
  • Mohsan Saeed

    (Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University)

  • Ursula Andreo

    (Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University)

  • Hyo-Young Chung

    (Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University)

  • Christine Espiritu

    (Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University)

  • Andrea D. Branch

    (Icahn School of Medicine at Mount Sinai)

  • Jose M. Silva

    (Icahn School of Medicine at Mount Sinai)

  • Charles M. Rice

    (Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University)

Abstract

Hepatitis C virus cannot replicate in cell culture unless it possesses adaptive mutations; here, expression of cellular factor SEC14L2 is shown to allow replication of diverse hepatitis C virus genotypes in several hepatoma cell lines by enhancing vitamin E-mediated protection against lipid peroxidation.

Suggested Citation

  • Mohsan Saeed & Ursula Andreo & Hyo-Young Chung & Christine Espiritu & Andrea D. Branch & Jose M. Silva & Charles M. Rice, 2015. "SEC14L2 enables pan-genotype HCV replication in cell culture," Nature, Nature, vol. 524(7566), pages 471-475, August.
    • Handle: RePEc:nat:nature:v:524:y:2015:i:7566:d:10.1038_nature14899
    DOI: 10.1038/nature14899
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    Cited by:

    1. Tiffany Benzine & Ryan Brandt & William C Lovell & Daisuke Yamane & Petra Neddermann & Raffaele De Francesco & Stanley M Lemon & Alan S Perelson & Ruian Ke & David R McGivern, 2017. "NS5A inhibitors unmask differences in functional replicase complex half-life between different hepatitis C virus strains," PLOS Pathogens, Public Library of Science, vol. 13(6), pages 1-20, June.

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