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Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism

Author

Listed:
  • Rushika M. Perera

    (Center for Cancer Research, Massachusetts General Hospital
    Center for Regenerative Medicine, Massachusetts General Hospital
    Harvard Medical School)

  • Svetlana Stoykova

    (Center for Cancer Research, Massachusetts General Hospital
    Center for Regenerative Medicine, Massachusetts General Hospital)

  • Brandon N. Nicolay

    (Center for Cancer Research, Massachusetts General Hospital
    Harvard Medical School)

  • Kenneth N. Ross

    (Center for Cancer Research, Massachusetts General Hospital
    Center for Regenerative Medicine, Massachusetts General Hospital
    Harvard Medical School)

  • Julien Fitamant

    (Center for Cancer Research, Massachusetts General Hospital
    Center for Regenerative Medicine, Massachusetts General Hospital
    Harvard Medical School)

  • Myriam Boukhali

    (Center for Cancer Research, Massachusetts General Hospital)

  • Justine Lengrand

    (Center for Cancer Research, Massachusetts General Hospital
    Center for Regenerative Medicine, Massachusetts General Hospital)

  • Vikram Deshpande

    (Harvard Medical School
    Massachusetts General Hospital)

  • Martin K. Selig

    (Massachusetts General Hospital)

  • Cristina R. Ferrone

    (Center for Cancer Research, Massachusetts General Hospital
    Harvard Medical School
    Massachusetts General Hospital)

  • Jeff Settleman

    (Center for Cancer Research, Massachusetts General Hospital)

  • Gregory Stephanopoulos

    (Massachusetts Institute of Technology)

  • Nicholas J. Dyson

    (Center for Cancer Research, Massachusetts General Hospital
    Harvard Medical School)

  • Roberto Zoncu

    (University of California at Berkeley)

  • Sridhar Ramaswamy

    (Center for Cancer Research, Massachusetts General Hospital
    Center for Regenerative Medicine, Massachusetts General Hospital
    Harvard Medical School)

  • Wilhelm Haas

    (Center for Cancer Research, Massachusetts General Hospital
    Harvard Medical School)

  • Nabeel Bardeesy

    (Center for Cancer Research, Massachusetts General Hospital
    Center for Regenerative Medicine, Massachusetts General Hospital
    Harvard Medical School)

Abstract

The MiT/TFE family of transcription factors is found to coordinate constitutive activation of autophagy and lysosome biogenesis to drive the metabolic programming and malignant growth of pancreatic cancer.

Suggested Citation

  • Rushika M. Perera & Svetlana Stoykova & Brandon N. Nicolay & Kenneth N. Ross & Julien Fitamant & Myriam Boukhali & Justine Lengrand & Vikram Deshpande & Martin K. Selig & Cristina R. Ferrone & Jeff Se, 2015. "Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism," Nature, Nature, vol. 524(7565), pages 361-365, August.
    • Handle: RePEc:nat:nature:v:524:y:2015:i:7565:d:10.1038_nature14587
    DOI: 10.1038/nature14587
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    Cited by:

    1. Yuanli Zhen & Kai Liu & Lei Shi & Simran Shah & Qin Xu & Haley Ellis & Eranga R. Balasooriya & Johannes Kreuzer & Robert Morris & Albert S. Baldwin & Dejan Juric & Wilhelm Haas & Nabeel Bardeesy, 2024. "FGFR inhibition blocks NF-ĸB-dependent glucose metabolism and confers metabolic vulnerabilities in cholangiocarcinoma," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Kaushal Asrani & Juhyung Woo & Adrianna A. Mendes & Ethan Schaffer & Thiago Vidotto & Clarence Rachel Villanueva & Kewen Feng & Lia Oliveira & Sanjana Murali & Hans B. Liu & Daniela C. Salles & Brando, 2022. "An mTORC1-mediated negative feedback loop constrains amino acid-induced FLCN-Rag activation in renal cells with TSC2 loss," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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