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The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1

Author

Listed:
  • Jinbo Han

    (MOE Key Laboratory of Bioinformatics, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University)

  • Erwei Li

    (MOE Key Laboratory of Bioinformatics, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University)

  • Liqun Chen

    (MOE Key Laboratory of Bioinformatics, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University)

  • Yuanyuan Zhang

    (MOE Key Laboratory of Bioinformatics, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University)

  • Fangchao Wei

    (MOE Key Laboratory of Bioinformatics, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University)

  • Jieyuan Liu

    (Proteomics Facility, School of Life Sciences, Tsinghua University)

  • Haiteng Deng

    (Proteomics Facility, School of Life Sciences, Tsinghua University)

  • Yiguo Wang

    (MOE Key Laboratory of Bioinformatics, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University)

Abstract

Studies in mice reveal that CREB regulated transcription coactivator 2 (CRTC2) acts as a mediator of mTOR signalling in the liver to regulate SREBP1-controlled lipid homeostasis during feeding and diabetes; overexpression of a CRTC2 mutant defective for mTOR regulation improves the lipogenic program and insulin sensitivity in obese mice.

Suggested Citation

  • Jinbo Han & Erwei Li & Liqun Chen & Yuanyuan Zhang & Fangchao Wei & Jieyuan Liu & Haiteng Deng & Yiguo Wang, 2015. "The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1," Nature, Nature, vol. 524(7564), pages 243-246, August.
    • Handle: RePEc:nat:nature:v:524:y:2015:i:7564:d:10.1038_nature14557
    DOI: 10.1038/nature14557
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    Cited by:

    1. Dongjin Pan & Yunzhu Yang & Aihua Nong & Zhenzhou Tang & Qing X. Li, 2022. "GRP78 Activity Moderation as a Therapeutic Treatment against Obesity," IJERPH, MDPI, vol. 19(23), pages 1-17, November.
    2. Wen Wei & Qiaoli Chen & Minjun Liu & Yang Sheng & Qian OuYang & Weikuan Feng & Xinyu Yang & Longfei Ding & Shu Su & Jingzi Zhang & Lei Fang & Antonio Vidal-Puig & Hong-Yu Wang & Shuai Chen, 2022. "TRIM24 is an insulin-responsive regulator of P-bodies," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Hailin Tu & Weihang Xiong & Jie Zhang & Xueqiang Zhao & Xin Lin, 2022. "Tyrosine phosphorylation regulates RIPK1 activity to limit cell death and inflammation," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    4. Lu Jin & Shuang Han & Xue Lv & Xiaofei Li & Ziyin Zhang & Henry Kuang & Zhimin Chen & Cheng-an Lv & Wei Peng & Zhuoying Yang & Miqi Yang & Lin Mi & Tongyu Liu & Shengshan Ma & Xinyuan Qiu & Qintao Wan, 2023. "The muscle-enriched myokine Musclin impairs beige fat thermogenesis and systemic energy homeostasis via Tfr1/PKA signaling in male mice," Nature Communications, Nature, vol. 14(1), pages 1-23, December.

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