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GRP78 Activity Moderation as a Therapeutic Treatment against Obesity

Author

Listed:
  • Dongjin Pan

    (Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China)

  • Yunzhu Yang

    (Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China)

  • Aihua Nong

    (Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China)

  • Zhenzhou Tang

    (Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China)

  • Qing X. Li

    (Department of Molecular Biosciences and Bioengineering, University of Hawaii at Manoa, 1955 East-West Road, Honolulu, HI 96822, USA)

Abstract

Glucose-regulated protein 78 (GRP78), a molecular chaperone, is overexpressed in patients suffering from obesity, fatty liver, hyperlipidemia and diabetes. GRP78, therefore, can be not only a biomarker to predict the progression and prognosis of obesity and metabolic diseases but also a potential therapeutic target for anti-obesity treatment. In this paper, GRP78 inhibitors targeting its ATPase domain have been reviewed. Small molecules and proteins that directly bind GRP78 have been described. Putative mechanisms of GRP78 in regulating lipid metabolism were also summarized so as to investigate the role of GRP78 in obesity and other related diseases and provide a theoretical basis for the development and design of anti-obesity drugs targeting GRP78.

Suggested Citation

  • Dongjin Pan & Yunzhu Yang & Aihua Nong & Zhenzhou Tang & Qing X. Li, 2022. "GRP78 Activity Moderation as a Therapeutic Treatment against Obesity," IJERPH, MDPI, vol. 19(23), pages 1-17, November.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:23:p:15965-:d:988829
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    References listed on IDEAS

    as
    1. Jinbo Han & Erwei Li & Liqun Chen & Yuanyuan Zhang & Fangchao Wei & Jieyuan Liu & Haiteng Deng & Yiguo Wang, 2015. "The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1," Nature, Nature, vol. 524(7564), pages 243-246, August.
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