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Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex

Author

Listed:
  • Lanfeng Wang

    (Skaggs School of Pharmacy and Pharmaceutical Sciences, The University of California, San Diego)

  • Yu Zhou

    (School of Medicine, The University of California, San Diego)

  • Liang Xu

    (Skaggs School of Pharmacy and Pharmaceutical Sciences, The University of California, San Diego)

  • Rui Xiao

    (School of Medicine, The University of California, San Diego)

  • Xingyu Lu

    (and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago)

  • Liang Chen

    (School of Medicine, The University of California, San Diego)

  • Jenny Chong

    (Skaggs School of Pharmacy and Pharmaceutical Sciences, The University of California, San Diego)

  • Hairi Li

    (School of Medicine, The University of California, San Diego)

  • Chuan He

    (and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago)

  • Xiang-Dong Fu

    (School of Medicine, The University of California, San Diego)

  • Dong Wang

    (Skaggs School of Pharmacy and Pharmaceutical Sciences, The University of California, San Diego)

Abstract

Structural and biochemical studies of RNA polymerase II (Pol II) assembled on DNA containing 5-carboxycytosine reveals that Pol II can sense the oxidized methylation state of DNA and transiently slows down during transcription.

Suggested Citation

  • Lanfeng Wang & Yu Zhou & Liang Xu & Rui Xiao & Xingyu Lu & Liang Chen & Jenny Chong & Hairi Li & Chuan He & Xiang-Dong Fu & Dong Wang, 2015. "Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex," Nature, Nature, vol. 523(7562), pages 621-625, July.
    • Handle: RePEc:nat:nature:v:523:y:2015:i:7562:d:10.1038_nature14482
    DOI: 10.1038/nature14482
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    Cited by:

    1. Qingqing Yan & Shuyi An & Liang Yu & Shenfang Li & Xiaonan Wu & Siqi Dong & Shunshun Xiong & Hao Wang & Sujing Wang & Jiangfeng Du, 2024. "A Ni4O4-cubane-squarate coordination framework for molecular recognition," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    2. Jianbing Ma & Gangshun Yi & Mingda Ye & Craig MacGregor-Chatwin & Yuewen Sheng & Ying Lu & Ming Li & Qingrong Li & Dong Wang & Robert J. C. Gilbert & Peijun Zhang, 2024. "Open architecture of archaea MCM and dsDNA complexes resolved using monodispersed streptavidin affinity CryoEM," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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