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Impermanence of dendritic spines in live adult CA1 hippocampus

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  • Alessio Attardo

    (James H. Clark Center for Biomedical Engineering & Sciences, Stanford University
    Howard Hughes Medical Institute, Stanford University
    †Present addresses: Max Planck Institute of Psychiatry, 80804 Munich, Germany (A.A.); Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA (J.E.F.).)

  • James E. Fitzgerald

    (James H. Clark Center for Biomedical Engineering & Sciences, Stanford University
    †Present addresses: Max Planck Institute of Psychiatry, 80804 Munich, Germany (A.A.); Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA (J.E.F.).)

  • Mark J. Schnitzer

    (James H. Clark Center for Biomedical Engineering & Sciences, Stanford University
    Howard Hughes Medical Institute, Stanford University
    CNC Program, Stanford University)

Abstract

A new microendoscopic method reveals that hippocampal dendritic spines in the CA1 region undergo a complete turnover in less than six weeks in adult mice; this contrasts with the much greater stability of synapses in the neocortex and provides a physical basis for the fact that episodic memories are only retained by the mouse hippocampus for a few weeks.

Suggested Citation

  • Alessio Attardo & James E. Fitzgerald & Mark J. Schnitzer, 2015. "Impermanence of dendritic spines in live adult CA1 hippocampus," Nature, Nature, vol. 523(7562), pages 592-596, July.
    • Handle: RePEc:nat:nature:v:523:y:2015:i:7562:d:10.1038_nature14467
    DOI: 10.1038/nature14467
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    Cited by:

    1. HaoRan Chang & Ingrid M. Esteves & Adam R. Neumann & Majid H. Mohajerani & Bruce L. McNaughton, 2023. "Cortical reactivation of spatial and non-spatial features coordinates with hippocampus to form a memory dialogue," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Roman Dvorkin & Noam E Ziv, 2016. "Relative Contributions of Specific Activity Histories and Spontaneous Processes to Size Remodeling of Glutamatergic Synapses," PLOS Biology, Public Library of Science, vol. 14(10), pages 1-33, October.

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