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Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart

Author

Listed:
  • Wataru Kimura

    (The University of Texas Southwestern Medical Center
    Life Science Center, Tsukuba Advanced Research Alliance, University of Tsukuba)

  • Feng Xiao

    (The University of Texas Southwestern Medical Center)

  • Diana C. Canseco

    (The University of Texas Southwestern Medical Center)

  • Shalini Muralidhar

    (The University of Texas Southwestern Medical Center)

  • SuWannee Thet

    (The University of Texas Southwestern Medical Center)

  • Helen M. Zhang

    (The University of Texas Southwestern Medical Center)

  • Yezan Abderrahman

    (The University of Texas Southwestern Medical Center)

  • Rui Chen

    (The University of Texas Southwestern Medical Center)

  • Joseph A. Garcia

    (The University of Texas Southwestern Medical Center
    VA North Texas Health Care System)

  • John M. Shelton

    (The University of Texas Southwestern Medical Center)

  • James A. Richardson

    (The University of Texas Southwestern Medical Center
    The University of Texas Southwestern Medical Center)

  • Abdelrahman M. Ashour

    (The University of Texas Southwestern Medical Center)

  • Aroumougame Asaithamby

    (The University of Texas Southwestern Medical Center)

  • Hanquan Liang

    (McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical Center)

  • Chao Xing

    (McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical Center)

  • Zhigang Lu

    (The University of Texas Southwestern Medical Center)

  • Cheng Cheng Zhang

    (The University of Texas Southwestern Medical Center)

  • Hesham A. Sadek

    (The University of Texas Southwestern Medical Center
    Hamon Center for Regenerative Science and Medicine, The University of Texas Southwestern Medical Center)

Abstract

Fate-mapping hypoxic cells in the mouse heart identifies a rare population of cycling cardiomyocytes, which show characteristics of neonatal cardiomyocytes, including smaller size and mononucleation, and contribute to new cardiomyocyte formation in the adult heart.

Suggested Citation

  • Wataru Kimura & Feng Xiao & Diana C. Canseco & Shalini Muralidhar & SuWannee Thet & Helen M. Zhang & Yezan Abderrahman & Rui Chen & Joseph A. Garcia & John M. Shelton & James A. Richardson & Abdelrahm, 2015. "Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart," Nature, Nature, vol. 523(7559), pages 226-230, July.
    • Handle: RePEc:nat:nature:v:523:y:2015:i:7559:d:10.1038_nature14582
    DOI: 10.1038/nature14582
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    Cited by:

    1. Yamei Liu & Shuya Wang & Jiaxiong Zhang & Quan Sun & Yi Xiao & Jing Chen & Meilian Yao & Guogang Zhang & Qun Huang & Tianjiao Zhao & Qiong Huang & Xiaojing Shi & Can Feng & Kelong Ai & Yongping Bai, 2024. "Reprogramming the myocardial infarction microenvironment with melanin-based composite nanomedicines in mice," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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