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Reprogramming the myocardial infarction microenvironment with melanin-based composite nanomedicines in mice

Author

Listed:
  • Yamei Liu

    (Central South University
    Central South University)

  • Shuya Wang

    (Central South University
    Central South University)

  • Jiaxiong Zhang

    (Central South University
    Central South University)

  • Quan Sun

    (Central South University
    Central South University)

  • Yi Xiao

    (Central South University
    Central South University)

  • Jing Chen

    (Central South University)

  • Meilian Yao

    (Central South University)

  • Guogang Zhang

    (Central South University
    Central South University
    Central South University)

  • Qun Huang

    (Hunan Provincial Maternal and Child Health Care Hospital)

  • Tianjiao Zhao

    (Central South University
    Central South University)

  • Qiong Huang

    (Central South University
    Central South University)

  • Xiaojing Shi

    (Central South University
    Central South University)

  • Can Feng

    (Central South University)

  • Kelong Ai

    (Central South University
    Central South University)

  • Yongping Bai

    (Central South University
    Central South University)

Abstract

Myocardial infarction (MI) has a 5-year mortality rate of more than 50% due to the lack of effective treatments. Interactions between cardiomyocytes and the MI microenvironment (MIM) can determine the progression and fate of infarcted myocardial tissue. Here, a specially designed Melanin-based composite nanomedicines (MCN) is developed to effectively treat MI by reprogramming the MIM. MCN is a nanocomposite composed of polydopamine (P), Prussian blue (PB) and cerium oxide (CexOy) with a Mayuan-like structure, which reprogramming the MIM by the efficient conversion of detrimental substances (H+, reactive oxygen species, and hypoxia) into beneficial status (O2 and H2O). In coronary artery ligation and ischemia reperfusion models of male mice, intravenously injecting MCN specifically targets the damaged area, resulting in restoration of cardiac function. With its promising therapeutic effects, MCN constitutes a new agent for MI treatment and demonstrates potential for clinical application.

Suggested Citation

  • Yamei Liu & Shuya Wang & Jiaxiong Zhang & Quan Sun & Yi Xiao & Jing Chen & Meilian Yao & Guogang Zhang & Qun Huang & Tianjiao Zhao & Qiong Huang & Xiaojing Shi & Can Feng & Kelong Ai & Yongping Bai, 2024. "Reprogramming the myocardial infarction microenvironment with melanin-based composite nanomedicines in mice," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50854-4
    DOI: 10.1038/s41467-024-50854-4
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    1. Geng Chen & Xiankun Wang & Qiwen Liao & Yunjun Ge & Haizhan Jiao & Qiang Chen & Yezhou Liu & Wenping Lyu & Lizhe Zhu & Gydo C. P. Zundert & Michael J. Robertson & Georgios Skiniotis & Yang Du & Hongli, 2022. "Structural basis for recognition of N-formyl peptides as pathogen-associated molecular patterns," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
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