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Activating positive memory engrams suppresses depression-like behaviour

Author

Listed:
  • Steve Ramirez

    (RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Massachusetts Institute of Technology)

  • Xu Liu
  • Christopher J. MacDonald

    (RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Massachusetts Institute of Technology)

  • Anthony Moffa

    (RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Massachusetts Institute of Technology)

  • Joanne Zhou

    (RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Massachusetts Institute of Technology)

  • Roger L. Redondo

    (RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Massachusetts Institute of Technology
    Howard Hughes Medical Institute, Massachusetts Institute of Technology)

  • Susumu Tonegawa

    (RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Massachusetts Institute of Technology
    Howard Hughes Medical Institute, Massachusetts Institute of Technology)

Abstract

Acute re-activation of a positive memory engram suppresses depression-like behaviour in mice exposed to chronic stress, mediated by a hippocampus–amygdala–nucleus-accumbens pathway.

Suggested Citation

  • Steve Ramirez & Xu Liu & Christopher J. MacDonald & Anthony Moffa & Joanne Zhou & Roger L. Redondo & Susumu Tonegawa, 2015. "Activating positive memory engrams suppresses depression-like behaviour," Nature, Nature, vol. 522(7556), pages 335-339, June.
    • Handle: RePEc:nat:nature:v:522:y:2015:i:7556:d:10.1038_nature14514
    DOI: 10.1038/nature14514
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    Cited by:

    1. Meng Wang & Ke Liu & Junxia Pan & Jialin Li & Pei Sun & Yongsheng Zhang & Longhui Li & Wenyan Guo & Qianqian Xin & Zhikai Zhao & Yurong Liu & Zhenqiao Zhou & Jing Lyu & Ting Zheng & Yunyun Han & Chunq, 2022. "Brain-wide projection reconstruction of single functionally defined neurons," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Stephanie L. Grella & Amanda H. Fortin & Evan Ruesch & John H. Bladon & Leanna F. Reynolds & Abby Gross & Monika Shpokayte & Christine Cincotta & Yosif Zaki & Steve Ramirez, 2022. "Reactivating hippocampal-mediated memories during reconsolidation to disrupt fear," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    3. Jeroen P. H. Verharen & Johannes W. Jong & Yichen Zhu & Stephan Lammel, 2023. "A computational analysis of mouse behavior in the sucrose preference test," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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