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Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus

Author

Listed:
  • Keisuke Mochida

    (Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology)

  • Yu Oikawa

    (Frontier Research Center, Tokyo Institute of Technology)

  • Yayoi Kimura

    (Advanced Medical Research Center, Yokohama City University)

  • Hiromi Kirisako

    (Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology
    CREST, Japan Science and Technology Agency)

  • Hisashi Hirano

    (Advanced Medical Research Center, Yokohama City University)

  • Yoshinori Ohsumi

    (Frontier Research Center, Tokyo Institute of Technology)

  • Hitoshi Nakatogawa

    (Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology
    CREST, Japan Science and Technology Agency)

Abstract

In yeast, the novel protein Atg40 is enriched in the cortical and cytoplasmic endoplasmic reticulum (ER), and loads these ER subdomains into autophagosomes to facilitate ER autophagy; Atg39 localizes to the perinuclear ER and induces autophagic sequestration of part of the nucleus, thus ensuring cell survival under nitrogen-deprived conditions.

Suggested Citation

  • Keisuke Mochida & Yu Oikawa & Yayoi Kimura & Hiromi Kirisako & Hisashi Hirano & Yoshinori Ohsumi & Hitoshi Nakatogawa, 2015. "Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus," Nature, Nature, vol. 522(7556), pages 359-362, June.
    • Handle: RePEc:nat:nature:v:522:y:2015:i:7556:d:10.1038_nature14506
    DOI: 10.1038/nature14506
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    Cited by:

    1. Taeko Sasaki & Yasuharu Kushida & Takuya Norizuki & Hidetaka Kosako & Ken Sato & Miyuki Sato, 2024. "ALLO-1- and IKKE-1-dependent positive feedback mechanism promotes the initiation of paternal mitochondrial autophagy," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Shuangcheng Alivia Wu & Chenchen Shen & Xiaoqiong Wei & Xiawei Zhang & Siwen Wang & Xinxin Chen & Mauricio Torres & You Lu & Liangguang Leo Lin & Huilun Helen Wang & Allen H. Hunter & Deyu Fang & Shen, 2023. "The mechanisms to dispose of misfolded proteins in the endoplasmic reticulum of adipocytes," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Ning Wang & Yoko Shibata & Joao A. Paulo & Steven P. Gygi & Tom A. Rapoport, 2023. "A conserved membrane curvature-generating protein is crucial for autophagosome formation in fission yeast," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    4. Yun Xiang & Rui Lyu & Junjie Hu, 2023. "Oligomeric scaffolding for curvature generation by ER tubule-forming proteins," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    5. Patricia González-Rodríguez & Daniel J. Klionsky & Bertrand Joseph, 2022. "Autophagy regulation by RNA alternative splicing and implications in human diseases," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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