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Regulation of endoplasmic reticulum turnover by selective autophagy

Author

Listed:
  • Aliaksandr Khaminets

    (Institute of Biochemistry II, Goethe University School of Medicine)

  • Theresa Heinrich

    (Institute of Human Genetics, Jena University Hospital, Friedrich-Schiller-University Jena)

  • Muriel Mari

    (Center for Molecular Medicine, University Medical Center Utrecht
    University Medical Center Utrecht, University of Groningen)

  • Paolo Grumati

    (Institute of Biochemistry II, Goethe University School of Medicine)

  • Antje K. Huebner

    (Institute of Human Genetics, Jena University Hospital, Friedrich-Schiller-University Jena)

  • Masato Akutsu

    (Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Riedberg Campus)

  • Lutz Liebmann

    (Institute of Human Genetics, Jena University Hospital, Friedrich-Schiller-University Jena)

  • Alexandra Stolz

    (Institute of Biochemistry II, Goethe University School of Medicine)

  • Sandor Nietzsche

    (Electron Microscopy Center, Jena University Hospital, Friedrich-Schiller-University Jena)

  • Nicole Koch

    (Institute for Biochemistry I, Jena University Hospital, Friedrich-Schiller-University Jena)

  • Mario Mauthe

    (Center for Molecular Medicine, University Medical Center Utrecht
    University Medical Center Utrecht, University of Groningen)

  • Istvan Katona

    (Institute of Neuropathology, RWTH Aachen University Hospital)

  • Britta Qualmann

    (Institute for Biochemistry I, Jena University Hospital, Friedrich-Schiller-University Jena)

  • Joachim Weis

    (Institute of Neuropathology, RWTH Aachen University Hospital)

  • Fulvio Reggiori

    (Center for Molecular Medicine, University Medical Center Utrecht
    University Medical Center Utrecht, University of Groningen)

  • Ingo Kurth

    (Institute of Human Genetics, Jena University Hospital, Friedrich-Schiller-University Jena)

  • Christian A. Hübner

    (Institute of Human Genetics, Jena University Hospital, Friedrich-Schiller-University Jena)

  • Ivan Dikic

    (Institute of Biochemistry II, Goethe University School of Medicine
    Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Riedberg Campus
    Institute of Immunology, School of Medicine University of Split)

Abstract

The protein FAM134B is an endoplasmic reticulum (ER)-resident receptor that facilitates ER autophagy, and downregulation of this protein (mutations of which are also known to cause sensory neuropathy in humans) results in expanded ER structures and degeneration of mouse sensory neurons.

Suggested Citation

  • Aliaksandr Khaminets & Theresa Heinrich & Muriel Mari & Paolo Grumati & Antje K. Huebner & Masato Akutsu & Lutz Liebmann & Alexandra Stolz & Sandor Nietzsche & Nicole Koch & Mario Mauthe & Istvan Kato, 2015. "Regulation of endoplasmic reticulum turnover by selective autophagy," Nature, Nature, vol. 522(7556), pages 354-358, June.
    • Handle: RePEc:nat:nature:v:522:y:2015:i:7556:d:10.1038_nature14498
    DOI: 10.1038/nature14498
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    Citations

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    Cited by:

    1. Shuangcheng Alivia Wu & Chenchen Shen & Xiaoqiong Wei & Xiawei Zhang & Siwen Wang & Xinxin Chen & Mauricio Torres & You Lu & Liangguang Leo Lin & Huilun Helen Wang & Allen H. Hunter & Deyu Fang & Shen, 2023. "The mechanisms to dispose of misfolded proteins in the endoplasmic reticulum of adipocytes," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Ryosuke Ishimura & Afnan H. El-Gowily & Daisuke Noshiro & Satoko Komatsu-Hirota & Yasuko Ono & Mayumi Shindo & Tomohisa Hatta & Manabu Abe & Takefumi Uemura & Hyeon-Cheol Lee-Okada & Tarek M. Mohamed , 2022. "The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    3. Marika K. Kucińska & Juliette Fedry & Carmela Galli & Diego Morone & Andrea Raimondi & Tatiana Soldà & Friedrich Förster & Maurizio Molinari, 2023. "TMX4-driven LINC complex disassembly and asymmetric autophagy of the nuclear envelope upon acute ER stress," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    4. Yu-Jie Chen & Jeffrey Knupp & Anoop Arunagiri & Leena Haataja & Peter Arvan & Billy Tsai, 2021. "PGRMC1 acts as a size-selective cargo receptor to drive ER-phagic clearance of mutant prohormones," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    5. Rayene Berkane & Hung Ho-Xuan & Marius Glogger & Pablo Sanz-Martinez & Lorène Brunello & Tristan Glaesner & Santosh Kumar Kuncha & Katharina Holzhüter & Sara Cano-Franco & Viviana Buonomo & Paloma Cab, 2023. "The function of ER-phagy receptors is regulated through phosphorylation-dependent ubiquitination pathways," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    6. Cathena Meiling Li & Jaemin Kang & Jongyeon Baek & Youbin Kim & Heemin Park & Yong-Keun Jung, 2024. "Cytosolic FKBPL and ER-resident CKAP4 co-regulates ER-phagy and protein secretion," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    7. Yun Xiang & Rui Lyu & Junjie Hu, 2023. "Oligomeric scaffolding for curvature generation by ER tubule-forming proteins," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    8. Patricia González-Rodríguez & Daniel J. Klionsky & Bertrand Joseph, 2022. "Autophagy regulation by RNA alternative splicing and implications in human diseases," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    9. Linliang Zhang & Hongyun Wang & Chao Han & Qi Dong & Jie Yan & Weiwei Guo & Chao Shan & Wen Zhao & Pu Chen & Rui Huang & Ying Wu & Yu Chen & Yali Qin & Mingzhou Chen, 2024. "AMFR-mediated Flavivirus NS2A ubiquitination subverts ER-phagy to augment viral pathogenicity," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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