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IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis

Author

Listed:
  • Seth B. Coffelt

    (Netherlands Cancer Institute)

  • Kelly Kersten

    (Netherlands Cancer Institute)

  • Chris W. Doornebal

    (Netherlands Cancer Institute)

  • Jorieke Weiden

    (Netherlands Cancer Institute)

  • Kim Vrijland

    (Netherlands Cancer Institute)

  • Cheei-Sing Hau

    (Netherlands Cancer Institute)

  • Niels J. M. Verstegen

    (Netherlands Cancer Institute)

  • Metamia Ciampricotti

    (Netherlands Cancer Institute)

  • Lukas J. A. C. Hawinkels

    (Leiden University Medical Center
    Centre for Biomedical Genetics, Leiden University Medical Center)

  • Jos Jonkers

    (Netherlands Cancer Institute)

  • Karin E. de Visser

    (Netherlands Cancer Institute)

Abstract

Tumours maximize their chance of metastasizing by evoking a systemic inflammatory cascade in mouse models of spontaneous breast cancer metastasis.

Suggested Citation

  • Seth B. Coffelt & Kelly Kersten & Chris W. Doornebal & Jorieke Weiden & Kim Vrijland & Cheei-Sing Hau & Niels J. M. Verstegen & Metamia Ciampricotti & Lukas J. A. C. Hawinkels & Jos Jonkers & Karin E., 2015. "IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis," Nature, Nature, vol. 522(7556), pages 345-348, June.
    • Handle: RePEc:nat:nature:v:522:y:2015:i:7556:d:10.1038_nature14282
    DOI: 10.1038/nature14282
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    Cited by:

    1. Juan F. Quintana & Matthew C. Sinton & Praveena Chandrasegaran & Agatha Nabilla Lestari & Rhiannon Heslop & Bachar Cheaib & John Ogunsola & Dieudonne Mumba Ngoyi & Nono-Raymond Kuispond Swar & Anneli , 2023. "γδ T cells control murine skin inflammation and subcutaneous adipose wasting during chronic Trypanosoma brucei infection," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Charlotte R. Bell & Victoria S. Pelly & Agrin Moeini & Shih-Chieh Chiang & Eimear Flanagan & Christian P. Bromley & Christopher Clark & Charles H. Earnshaw & Maria A. Koufaki & Eduardo Bonavita & Sant, 2022. "Chemotherapy-induced COX-2 upregulation by cancer cells defines their inflammatory properties and limits the efficacy of chemoimmunotherapy combinations," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Scott C. Lien & Dalam Ly & S. Y. Cindy Yang & Ben X. Wang & Derek L. Clouthier & Michael St. Paul & Ramy Gadalla & Babak Noamani & Carlos R. Garcia-Batres & Sarah Boross-Harmer & Philippe L. Bedard & , 2024. "Tumor reactive γδ T cells contribute to a complete response to PD-1 blockade in a Merkel cell carcinoma patient," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    4. Derek Lee & Zachary Spencer Dunn & Wenbin Guo & Carl J. Rosenthal & Natalie E. Penn & Yanqi Yu & Kuangyi Zhou & Zhe Li & Feiyang Ma & Miao Li & Tsun-Ching Song & Xinjian Cen & Yan-Ruide Li & Jin J. Zh, 2023. "Unlocking the potential of allogeneic Vδ2 T cells for ovarian cancer therapy through CD16 biomarker selection and CAR/IL-15 engineering," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    5. Nicolaj S. Hackert & Felix A. Radtke & Tarik Exner & Hanns-Martin Lorenz & Carsten Müller-Tidow & Peter A. Nigrovic & Guido Wabnitz & Ricardo Grieshaber-Bouyer, 2023. "Human and mouse neutrophils share core transcriptional programs in both homeostatic and inflamed contexts," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    6. Ruolin Li & Wenjin Luo & Xiangjun Chen & Qinglian Zeng & Shumin Yang & Ping Wang & Jinbo Hu & Aijun Chen, 2024. "An observational and genetic investigation into the association between psoriasis and risk of malignancy," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    7. Laura C. D. Pomatto-Watson & Monica Bodogai & Oye Bosompra & Jonathan Kato & Sarah Wong & Melissa Carpenter & Eleonora Duregon & Dolly Chowdhury & Priya Krishna & Sandy Ng & Emeline Ragonnaud & Robert, 2021. "Daily caloric restriction limits tumor growth more effectively than caloric cycling regardless of dietary composition," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    8. Junho Lee & Donggu Lee & Sean Lawler & Yangjin Kim, 2021. "Role of neutrophil extracellular traps in regulation of lung cancer invasion and metastasis: Structural insights from a computational model," PLOS Computational Biology, Public Library of Science, vol. 17(2), pages 1-29, February.
    9. Jian Cao & Xuan Zhu & Xiaokun Zhao & Xue-Feng Li & Ran Xu, 2016. "Neutrophil-to-Lymphocyte Ratio Predicts PSA Response and Prognosis in Prostate Cancer: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(7), pages 1-15, July.

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