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Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo

Author

Listed:
  • Fadi J. Najm

    (Case Western Reserve University School of Medicine)

  • Mayur Madhavan

    (Case Western Reserve University School of Medicine)

  • Anita Zaremba

    (Case Western Reserve University School of Medicine)

  • Elizabeth Shick

    (Case Western Reserve University School of Medicine)

  • Robert T. Karl

    (Case Western Reserve University School of Medicine)

  • Daniel C. Factor

    (Case Western Reserve University School of Medicine)

  • Tyler E. Miller

    (Case Western Reserve University School of Medicine
    Case Western Reserve University School of Medicine
    Lerner Research Institute)

  • Zachary S. Nevin

    (Case Western Reserve University School of Medicine)

  • Christopher Kantor

    (Case Western Reserve University School of Medicine)

  • Alex Sargent

    (Case Western Reserve University School of Medicine)

  • Kevin L. Quick

    (PerkinElmer)

  • Daniela M. Schlatzer

    (Center for Proteomics and Bioinformatics, Case Western Reserve University School of Medicine)

  • Hong Tang

    (Drug Discovery Center, University of Cincinnati College of Medicine)

  • Ruben Papoian

    (Drug Discovery Center, University of Cincinnati College of Medicine
    †Present addresses: Department of Neurology & Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA (R.P.); Department of Anatomy & Regenerative Biology, George Washington University School of Medicine and Health Sciences, Washington DC 20037, USA (R.H.M.).)

  • Kyle R. Brimacombe

    (National Center for Advancing Translational Sciences, National Institutes of Health)

  • Min Shen

    (National Center for Advancing Translational Sciences, National Institutes of Health)

  • Matthew B. Boxer

    (National Center for Advancing Translational Sciences, National Institutes of Health)

  • Ajit Jadhav

    (National Center for Advancing Translational Sciences, National Institutes of Health)

  • Andrew P. Robinson

    (Feinberg School of Medicine, Northwestern University)

  • Joseph R. Podojil

    (Feinberg School of Medicine, Northwestern University)

  • Stephen D. Miller

    (Feinberg School of Medicine, Northwestern University)

  • Robert H. Miller

    (Case Western Reserve University School of Medicine
    †Present addresses: Department of Neurology & Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA (R.P.); Department of Anatomy & Regenerative Biology, George Washington University School of Medicine and Health Sciences, Washington DC 20037, USA (R.H.M.).)

  • Paul J. Tesar

    (Case Western Reserve University School of Medicine
    Case Western Reserve University School of Medicine)

Abstract

Two drugs, miconazole and clobetasol, have functions that modulate differentiation of oligodendrocyte progenitor cells directly, enhance remyelination, and significantly reduce disease severity in mouse models of multiple sclerosis.

Suggested Citation

  • Fadi J. Najm & Mayur Madhavan & Anita Zaremba & Elizabeth Shick & Robert T. Karl & Daniel C. Factor & Tyler E. Miller & Zachary S. Nevin & Christopher Kantor & Alex Sargent & Kevin L. Quick & Daniela , 2015. "Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo," Nature, Nature, vol. 522(7555), pages 216-220, June.
    • Handle: RePEc:nat:nature:v:522:y:2015:i:7555:d:10.1038_nature14335
    DOI: 10.1038/nature14335
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    Citations

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    Cited by:

    1. Laura J. Wagstaff & Nadine Bestard-Cuche & Maja Kaczmarek & Antonella Fidanza & Lorraine McNeil & Robin J. M. Franklin & Anna C. Williams, 2024. "CRISPR-edited human ES-derived oligodendrocyte progenitor cells improve remyelination in rodents," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Sophie Martin & Kevin C. Allan & Otis Pinkard & Thomas Sweet & Paul J. Tesar & Jeff Coller, 2022. "Oligodendrocyte differentiation alters tRNA modifications and codon optimality-mediated mRNA decay," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    3. Jean-Baptiste Huré & Louis Foucault & Litsa Maria Ghayad & Corentine Marie & Nicolas Vachoud & Lucas Baudouin & Rihab Azmani & Natalija Ivjanin & Alvaro Arevalo-Nuevo & Morgane Pigache & Lamia Bouslam, 2024. "Pharmacogenomic screening identifies and repurposes leucovorin and dyclonine as pro-oligodendrogenic compounds in brain repair," Nature Communications, Nature, vol. 15(1), pages 1-24, December.
    4. Giampiero Porcu & Eliseo Serone & Velia De Nardis & Daniele Di Giandomenico & Giuseppe Lucisano & Marco Scardapane & Anna Poma & Antonella Ragnini-Wilson, 2015. "Clobetasol and Halcinonide Act as Smoothened Agonists to Promote Myelin Gene Expression and RxRγ Receptor Activation," PLOS ONE, Public Library of Science, vol. 10(12), pages 1-22, December.
    5. Jaime Gonzalez Cardona & Matthew D Smith & Jingya Wang & Leslie Kirby & Jason T Schott & Todd Davidson & Jodi L Karnell & Katharine A Whartenby & Peter A Calabresi, 2019. "Quetiapine has an additive effect to triiodothyronine in inducing differentiation of oligodendrocyte precursor cells through induction of cholesterol biosynthesis," PLOS ONE, Public Library of Science, vol. 14(9), pages 1-19, September.

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