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RETRACTED ARTICLE: The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase

Author

Listed:
  • Thomas R. Cox

    (Biotech Research and Innovation Centre (BRIC), University of Copenhagen (UCPH)
    Hypoxia and Metastasis Team, Cancer Research UK Tumour Cell Signalling Unit, The Institute of Cancer Research)

  • Robin M. H. Rumney

    (The Mellanby Centre for Bone Research, The University of Sheffield)

  • Erwin M. Schoof

    (Cellular Signal Integration Group (C-SIG), Technical University of Denmark (DTU), Lyngby, DK-2800, Denmark)

  • Lara Perryman

    (Biotech Research and Innovation Centre (BRIC), University of Copenhagen (UCPH))

  • Anette M. Høye

    (Biotech Research and Innovation Centre (BRIC), University of Copenhagen (UCPH))

  • Ankita Agrawal

    (The Mellanby Centre for Bone Research, The University of Sheffield)

  • Demelza Bird

    (Hypoxia and Metastasis Team, Cancer Research UK Tumour Cell Signalling Unit, The Institute of Cancer Research)

  • Norain Ab Latif

    (The Mellanby Centre for Bone Research, The University of Sheffield)

  • Hamish Forrest

    (The Mellanby Centre for Bone Research, The University of Sheffield)

  • Holly R. Evans

    (The Mellanby Centre for Bone Research, The University of Sheffield)

  • Iain D. Huggins

    (The Mellanby Centre for Bone Research, The University of Sheffield)

  • Georgina Lang

    (Hypoxia and Metastasis Team, Cancer Research UK Tumour Cell Signalling Unit, The Institute of Cancer Research)

  • Rune Linding

    (Biotech Research and Innovation Centre (BRIC), University of Copenhagen (UCPH)
    Cellular Signal Integration Group (C-SIG), Technical University of Denmark (DTU), Lyngby, DK-2800, Denmark)

  • Alison Gartland

    (The Mellanby Centre for Bone Research, The University of Sheffield)

  • Janine T. Erler

    (Biotech Research and Innovation Centre (BRIC), University of Copenhagen (UCPH)
    Hypoxia and Metastasis Team, Cancer Research UK Tumour Cell Signalling Unit, The Institute of Cancer Research)

Abstract

Metastasis to the bone of certain breast cancers can be driven by the enzyme lysyl oxidase (LOX) produced by primary tumour cells.

Suggested Citation

  • Thomas R. Cox & Robin M. H. Rumney & Erwin M. Schoof & Lara Perryman & Anette M. Høye & Ankita Agrawal & Demelza Bird & Norain Ab Latif & Hamish Forrest & Holly R. Evans & Iain D. Huggins & Georgina L, 2015. "RETRACTED ARTICLE: The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase," Nature, Nature, vol. 522(7554), pages 106-110, June.
    • Handle: RePEc:nat:nature:v:522:y:2015:i:7554:d:10.1038_nature14492
    DOI: 10.1038/nature14492
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    Cited by:

    1. Qing Li & Xiao-Xin Zhang & Li-Peng Hu & Bo Ni & Dong-Xue Li & Xu Wang & Shu-Heng Jiang & Hui Li & Min-Wei Yang & Yong-Sheng Jiang & Chun-Jie Xu & Xue-Li Zhang & Yan-Li Zhang & Pei-Qi Huang & Qin Yang , 2023. "Coadaptation fostered by the SLIT2-ROBO1 axis facilitates liver metastasis of pancreatic ductal adenocarcinoma," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    2. Silje Kjølle & Kenneth Finne & Even Birkeland & Vandana Ardawatia & Ingeborg Winge & Sura Aziz & Gøril Knutsvik & Elisabeth Wik & Joao A. Paulo & Heidrun Vethe & Dimitrios Kleftogiannis & Lars A. Aksl, 2023. "Hypoxia induced responses are reflected in the stromal proteome of breast cancer," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. Eli Elyas & Alex Grimwood & Janine T Erler & Simon P Robinson & Thomas R Cox & Daniel Woods & Peter Clowes & Ramona De Luca & Franco Marinozzi & Jérémie Fromageau & Jeffrey C Bamber, 2017. "Multi-Channel Optical Coherence Elastography Using Relative and Absolute Shear-Wave Time of Flight," PLOS ONE, Public Library of Science, vol. 12(1), pages 1-18, January.

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