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Counteraction of antibiotic production and degradation stabilizes microbial communities

Author

Listed:
  • Eric D. Kelsic

    (Harvard Medical School)

  • Jeffrey Zhao

    (Harvard Medical School)

  • Kalin Vetsigian

    (University of Wisconsin-Madison)

  • Roy Kishony

    (Harvard Medical School
    Technion-Israel Institute of Technology)

Abstract

Mathematical modelling and simulations reveal that including antibiotic degraders in ecological models of microbial species interaction allows the system to robustly move towards an intermixed stable state, more representative of real-world observations.

Suggested Citation

  • Eric D. Kelsic & Jeffrey Zhao & Kalin Vetsigian & Roy Kishony, 2015. "Counteraction of antibiotic production and degradation stabilizes microbial communities," Nature, Nature, vol. 521(7553), pages 516-519, May.
    • Handle: RePEc:nat:nature:v:521:y:2015:i:7553:d:10.1038_nature14485
    DOI: 10.1038/nature14485
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    Citations

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    Cited by:

    1. Eran Even-Tov & Shira Omer Bendori & Julie Valastyan & Xiaobo Ke & Shaul Pollak & Tasneem Bareia & Ishay Ben-Zion & Bonnie L Bassler & Avigdor Eldar, 2016. "Social Evolution Selects for Redundancy in Bacterial Quorum Sensing," PLOS Biology, Public Library of Science, vol. 14(2), pages 1-18, February.
    2. Yang, Xinbin & Xu, Xinming & Hu, Dawei, 2020. "Succession mechanism of microbial community with high species diversity in nutrient-deficient environments with low-dose ionizing radiation," Ecological Modelling, Elsevier, vol. 435(C).
    3. Zhang, Zeyu & Bearup, Daniel & Guo, Guanming & Zhang, Helin & Liao, Jinbao, 2022. "Competition modes determine ecosystem stability in rock–paper–scissors games," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 607(C).
    4. Søren Christensen & Wilhelmina H. Gera Hol & Viola Kurm & Mette Vestergård, 2021. "Increased Likelihood of High Nitrous Oxide (N 2 O) Exchange in Soils at Reduced Microbial Diversity," Sustainability, MDPI, vol. 13(4), pages 1-8, February.
    5. Gerrit Ansmann & Tobias Bollenbach, 2021. "Building clone-consistent ecosystem models," PLOS Computational Biology, Public Library of Science, vol. 17(2), pages 1-25, February.
    6. Zhang, Xiaojun & Li, Baohuan, 2024. "Information sharing promotes bacterial diversity in oligotrophic environment with low-dose X-ray radiation based on modeling and simulation of agent-based model," Ecological Modelling, Elsevier, vol. 488(C).
    7. Li Xie & Wenying Shou, 2021. "Steering ecological-evolutionary dynamics to improve artificial selection of microbial communities," Nature Communications, Nature, vol. 12(1), pages 1-15, December.

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